ML350 , also known as CYM-50202, is an antagonist of KOR (IC50 = 12.6 nM) with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility, an encouraging pharmacokinetic (PK) profile in rat, and excellent CNS penetration. Perhaps more importantly, CYM-50202 did not display long lasting pharmacodynamic effects observed with prototypical KOR antagonists.
MedKoo Cat#: 563333
Name: ML350
CAS#: 1565852-90-5
Chemical Formula: C18H26BrN3O3
Exact Mass: 411.1158
Molecular Weight: 412.32
Elemental Analysis: C, 52.43; H, 6.36; Br, 19.38; N, 10.19; O, 11.64
The following data is based on the product molecular weight 412.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
