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MedKoo Cat#: 597981 | Name: Thr8-saralasin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thr8-saralasin is an angiotensin antagonist.

Chemical Structure

Thr8-saralasin
Thr8-saralasin
CAS#74127-89-2

Theoretical Analysis

MedKoo Cat#: 597981

Name: Thr8-saralasin

CAS#: 74127-89-2

Chemical Formula: C43H67N13O11

Exact Mass: 941.5083

Molecular Weight: 942.08

Elemental Analysis: C, 54.82; H, 7.17; N, 19.33; O, 18.68

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Thr8-saralasin;
IUPAC/Chemical Name
(6S,9S,12S,15S,18S)-18-(((R)-4H-imidazol-4-yl)methyl)-6-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9,15-diisopropyl-4,7,10,13,16-pentaoxo-2,5,8,11,14,17-hexaazanonadecan-19-oic (2S,3R)-3-hydroxy-2-((S)-pyrrolidine-2-carboxamido)butanoic anhydride
InChi Key
PUHVDWPGYSQGRB-CYBNBNGASA-N
InChi Code
InChI=1S/C43H67N13O11/c1-22(2)33(54-37(61)29(51-32(59)20-46-6)10-8-16-49-43(44)45)39(63)52-30(17-25-11-13-27(58)14-12-25)38(62)55-34(23(3)4)40(64)53-31(18-26-19-47-21-50-26)41(65)67-42(66)35(24(5)57)56-36(60)28-9-7-15-48-28/h11-14,19,21-24,26,28-31,33-35,46,48,57-58H,7-10,15-18,20H2,1-6H3,(H,51,59)(H,52,63)(H,53,64)(H,54,61)(H,55,62)(H,56,60)(H4,44,45,49)/t24-,26-,28+,29+,30+,31+,33+,34+,35+/m1/s1
SMILES Code
O=C([C@H]1NCCC1)N[C@@H]([C@H](O)C)C(OC([C@H](C[C@@H]2C=NC=N2)NC([C@H](C(C)C)NC([C@H](Cc3ccc(O)cc3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC(CNC)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 942.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bravo EL, Khosla MC, Bumpus FM. Comparative studies of the humoral and arterial pressure responses to Sar1-Ala8-, Sar1-Ile8 and Sar1-Thr8-angiotensin II in the trained unanaesthetized dog. Prog Biochem Pharmacol. 1976;12:33-40. PubMed PMID: 1019168. 2: Muñoz-Ramírez H, Khosla MC, Bumpus FM, Khairallah PA. Hypotensive effect of [Sar1,Thr8]angiotensin II in spontaneously hypertensive sodium-depleted rats. Am J Physiol. 1978 Apr;234(4):H447-53. PubMed PMID: 645884. 3: Hata T, Ogihara T, Nakamaru M, Gotoh S, Masuo K, Saeki S, Kumagai A, Kumahara Y. Effect of three angiotensin II antagonists, [Sar1, Thr8]-, [Sar1, Ile8]- and [Sar1, Ala8]angiotensin II on blood pressure and endocrine factors in normal subjects. Eur J Clin Pharmacol. 1982;23(1):7-10. PubMed PMID: 6751836. 4: Stefas L, Levy BI. Effects of saralasin on arterial compliance in normotensive and hypertensive rats. Role of endothelium. Hypertension. 1991 Oct;18(4 Suppl):II30-6. PubMed PMID: 1916999. 5: Levy BI, Stefas L, Babalis D, Benetos A. Vascular endothelium, mechanical properties of the arterial wall and local angiotensin converting enzyme inhibition. J Hypertens Suppl. 1992 Jul;10(5):S21-7. PubMed PMID: 1328566. 6: Sen S, Tarazi RC, Bumpus FM. Cardiac effects of angiotensin antagonists in normotensive rats. Clin Sci (Lond). 1979 May;56(5):439-43. PubMed PMID: 157829. 7: Bumpus FM, Khosla MC. Pathogenic factors involved in renovascular hypertension. State of the art. Mayo Clin Proc. 1977 Jul;52(7):417-23. Review. PubMed PMID: 327161. 8: Propper CR, Johnson WE. Angiotensin II induces water absorption behavior in two species of desert anurans. Horm Behav. 1994 Mar;28(1):41-52. PubMed PMID: 8034281. 9: Fouad FM, Gifford RW Jr, Fighali S, Mujais SK, Novick AC, Bravo EL, Tarazi RC. Predictive value of angiotensin II antagonists in renovascular hypertension. JAMA. 1983 Jan 21;249(3):368-73. PubMed PMID: 6336802. 10: Schiavone MT, Santos RA, Brosnihan KB, Khosla MC, Ferrario CM. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc Natl Acad Sci U S A. 1988 Jun;85(11):4095-8. PubMed PMID: 3375255; PubMed Central PMCID: PMC280369. 11: Haas HL, Felix D, Celio MR, Inagami T. Angiotensin II in the hippocampus. A histochemical and electrophysiological study. Experientia. 1980 Dec 15;36(12):1394-5. PubMed PMID: 7202646. 12: Banks RO. Effects of endothelin on renal function in dogs and rats. Am J Physiol. 1990 Apr;258(4 Pt 2):F775-80. PubMed PMID: 2184673. 13: Blair-West JR, Coghlan JP, Denton DA, Niall HD, Scoggins BA, Tregear GW. Angiotensin II analogues and aldosterone secretion in sodium-deficient sheep. Clin Sci Mol Med Suppl. 1976 Dec;3:325s-327s. PubMed PMID: 1071638. 14: Silldorff EP, Stephens GA. The pressor response to exogenous angiotensin I and its blockade by angiotensin II analogues in the American alligator. Gen Comp Endocrinol. 1992 Jul;87(1):141-8. PubMed PMID: 1624094. 15: Weld MM, Fryer JN. Stimulation by angiotensins I and II of ACTH release from goldfish pituitary cell columns. Gen Comp Endocrinol. 1987 Oct;68(1):19-27. PubMed PMID: 2822525. 16: Bumpus FM, Khosla MC. Inhibition of the pressor and aldosterone-releasing effects of angiotensin II. Clin Sci Mol Med Suppl. 1975 Jun;2:15s-18s. PubMed PMID: 1077765. 17: Nishimura H, Norton VM, Bumpus FM. Lack of specific inhibition of angiotensin II in eels by angiotensin antagonists. Am J Physiol. 1978 Jul;235(1):H95-103. PubMed PMID: 677333.