MedKoo Cat#: 563331 | Name: Me6TREN 4HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Me6TREN 4HCl is a potent and efficacious mobilizing agent of hematopoietic stem and progenitor cells (HSPCs). It acts by activating MMP-9 expression and disrupting the SDF-1α/CXCR4 axis, exhibiting more significant mobilizing effects than G-CSF or AMD3100.

Chemical Structure

Me6TREN 4HCl
Me6TREN 4HCl
CAS#859322-03-5

Theoretical Analysis

MedKoo Cat#: 563331

Name: Me6TREN 4HCl

CAS#: 859322-03-5

Chemical Formula: C12H34Cl4N4

Exact Mass: 374.1538

Molecular Weight: 376.23

Elemental Analysis: C, 38.31; H, 9.11; Cl, 37.69; N, 14.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Me6TREN 4HCl; Me6TREN Tetrahydrochloride; Me6 4HCl; Me 6 4HCl; Me-6 4HCl; Me6-TREN Tetrahydrochloride;
IUPAC/Chemical Name
Tris[2-(dimethylamino)ethyl]amine tetrahydrochloride
InChi Key
XWPUVAUNZAITDT-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H30N4.4ClH/c1-13(2)7-10-16(11-8-14(3)4)12-9-15(5)6;;;;/h7-12H2,1-6H3;4*1H
SMILES Code
CN(CCN(CCN(C)C)CCN(C)C)C.[H]Cl.[H]Cl.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 376.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Banerjee S, Ankur, Andrews A, Venugopal A. A disguised hydride in a butylmagnesium cation. Chem Commun (Camb). 2018 May 31;54(45):5788-5791. doi: 10.1039/c8cc03127d. PubMed PMID: 29781487. 2: Li WL, Chiou TW, Chen CH, Yu YJ, Chu LK, Liaw WF. Electrodeposited-film electrodes derived from a precursor dinitrosyl iron complex for electrocatalytic water splitting. Dalton Trans. 2018 May 29;47(21):7128-7134. doi: 10.1039/c8dt00601f. PubMed PMID: 29756619. 3: Fan Y, Cao H, van Mastrigt F, Pei Y, Picchioni F. Copper-mediated homogeneous living radical polymerization of acrylamide with waxy potato starch-based macroinitiator. Carbohydr Polym. 2018 Jul 15;192:61-68. doi: 10.1016/j.carbpol.2018.03.041. Epub 2018 Mar 15. PubMed PMID: 29691035. 4: Krys P, Fantin M, Mendonça PV, Abreu CMR, Guliashvili T, Rosa J, Santos LO, Serra AC, Matyjaszewski K, Coelho JFJ. Mechanism of Supplemental Activator and Reducing Agent Atom Transfer Radical Polymerization Mediated by Inorganic Sulfites: Experimental Measurements and Kinetic Simulations. Polym Chem. 2017 Nov 14;8(42):6506-6519. doi: 10.1039/C7PY01319A. Epub 2017 Sep 22. PubMed PMID: 29422955; PubMed Central PMCID: PMC5814143. 5: Moreno A, Garcia D, Galià M, Ronda JC, Cádiz V, Lligadas G, Percec V. SET-LRP in the Neoteric Ethyl Lactate Alcohol. Biomacromolecules. 2017 Oct 9;18(10):3447-3456. doi: 10.1021/acs.biomac.7b01130. Epub 2017 Sep 27. PubMed PMID: 28891645. 6: Ojeda-Amador AI, Martínez-Martínez AJ, Robertson GM, Robertson SD, Kennedy AR, O'Hara CT. Exploring the solid state and solution structural chemistry of the utility amide potassium hexamethyldisilazide (KHMDS). Dalton Trans. 2017 May 16;46(19):6392-6403. doi: 10.1039/c7dt01118k. PubMed PMID: 28466908. 7: Van Hout A, D'huys T, Oeyen M, Schols D, Van Loy T. Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors. PLoS One. 2017 Apr 14;12(4):e0176057. doi: 10.1371/journal.pone.0176057. eCollection 2017. PubMed PMID: 28410420; PubMed Central PMCID: PMC5391968. 8: Frank P, Szilagyi RK, Gramlich V, Hsu HF, Hedman B, Hodgson KO. Spin-Polarization-Induced Preedge Transitions in the Sulfur K-Edge XAS Spectra of Open-Shell Transition-Metal Sulfates: Spectroscopic Validation of σ-Bond Electron Transfer. Inorg Chem. 2017 Feb 6;56(3):1080-1093. doi: 10.1021/acs.inorgchem.6b00991. Epub 2017 Jan 9. PubMed PMID: 28068071; PubMed Central PMCID: PMC5733802. 9: Borská K, Moravčíková D, Mosnáček J. Photochemically Induced ATRP of (Meth)Acrylates in the Presence of Air: The Effect of Light Intensity, Ligand, and Oxygen Concentration. Macromol Rapid Commun. 2017 Jul;38(13). doi: 10.1002/marc.201600639. Epub 2016 Dec 22. PubMed PMID: 28004494. 10: Hatton FL, Kedzior SA, Cranston ED, Carlmark A. Grafting-from cellulose nanocrystals via photoinduced Cu-mediated reversible-deactivation radical polymerization. Carbohydr Polym. 2017 Feb 10;157:1033-1040. doi: 10.1016/j.carbpol.2016.10.064. Epub 2016 Oct 21. PubMed PMID: 27987803. 11: Zerk TJ, Martinez M, Bernhardt PV. A Kinetico-Mechanistic Study on Cu(II) Deactivators Employed in Atom Transfer Radical Polymerization. Inorg Chem. 2016 Oct 3;55(19):9848-9857. Epub 2016 Sep 22. PubMed PMID: 27657311. 12: Mukherjee D, Osseili H, Spaniol TP, Okuda J. Alkali Metal Hydridotriphenylborates [(L)M][HBPh3] (M = Li, Na, K): Chemoselective Catalysts for Carbonyl and CO2 Hydroboration. J Am Chem Soc. 2016 Aug 31;138(34):10790-3. doi: 10.1021/jacs.6b06319. Epub 2016 Aug 16. PubMed PMID: 27513460. 13: Oseland EE, Ayres ZJ, Basile A, Haddleton DM, Wilson P, Unwin PR. Surface patterning of polyacrylamide gel using scanning electrochemical cell microscopy (SECCM). Chem Commun (Camb). 2016 Aug 2;52(64):9929-32. doi: 10.1039/c6cc05153g. PubMed PMID: 27430961. 14: Ojeda-Amador AI, Martínez-Martínez AJ, Kennedy AR, O'Hara CT. Structural Studies of Cesium, Lithium/Cesium, and Sodium/Cesium Bis(trimethylsilyl)amide (HMDS) Complexes. Inorg Chem. 2016 Jun 6;55(11):5719-28. doi: 10.1021/acs.inorgchem.6b00839. Epub 2016 May 13. PubMed PMID: 27177080. 15: Shao F, Cahier B, Guihéry N, Rivière E, Guillot R, Barra AL, Lan Y, Wernsdorfer W, Campbell VE, Mallah T. Tuning the Ising-type anisotropy in trigonal bipyramidal Co(II) complexes. Chem Commun (Camb). 2015 Nov 28;51(92):16475-8. doi: 10.1039/c5cc07741a. PubMed PMID: 26440770. 16: Ojeda-Amador AI, Martínez-Martínez AJ, Kennedy AR, O'Hara CT. Synthetic and Structural Studies of Mixed Sodium Bis(trimethylsilyl)amide/Sodium Halide Aggregates in the Presence of η(2)-N,N-, η(3)-N,N,N/N,O,N-, and η(4)-N,N,N,N-Donor Ligands. Inorg Chem. 2015 Oct 19;54(20):9833-44. doi: 10.1021/acs.inorgchem.5b01584. Epub 2015 Sep 29. PubMed PMID: 26417943. 17: Leich V, Spaniol TP, Okuda J. Formation of α-[KSiH3] by hydrogenolysis of potassium triphenylsilyl. Chem Commun (Camb). 2015 Oct 11;51(79):14772-4. doi: 10.1039/c5cc06187c. Epub 2015 Aug 24. PubMed PMID: 26299566. 18: Gao Y, Zhao T, Zhou D, Greiser U, Wang W. Insights into relevant mechanistic aspects about the induction period of Cu(0)/Me(6)TREN-mediated reversible-deactivation radical polymerization. Chem Commun (Camb). 2015 Oct 4;51(77):14435-8. doi: 10.1039/c5cc05189d. Epub 2015 Aug 3. PubMed PMID: 26234530. 19: Robertson SD, Kennedy AR, Liggat JJ, Mulvey RE. Facile synthesis of a genuinely alkane-soluble but isolable lithium hydride transfer reagent. Chem Commun (Camb). 2015 Mar 28;51(25):5452-5. doi: 10.1039/c4cc06421f. PubMed PMID: 25236757. 20: Chen H, Wang S, Zhang J, Ren X, Zhang R, Shi W, Lv Y, Zhou Y, Yan X, Chen L, He L, Zhang B, Nan X, Yue W, Li Y, Pei X. A novel molecule Me6TREN promotes angiogenesis via enhancing endothelial progenitor cell mobilization and recruitment. Sci Rep. 2014 Aug 28;4:6222. doi: 10.1038/srep06222. PubMed PMID: 25164363; PubMed Central PMCID: PMC5385830.