KSCM-1 | CAS#1415247-17-4 | sigma-1 receptor ligand

MedKoo Cat#: 563327 | Name: KSCM-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KSCM-1 is a selective ligand of the sigma-1 receptor.

Chemical Structure

KSCM-1

CAS#1415247-17-4

Theoretical Analysis

MedKoo Cat#: 563327

Name: KSCM-1

CAS#: 1415247-17-4

Chemical Formula: C26H32N2O4

Exact Mass: 436.2362

Molecular Weight: 436.55

Elemental Analysis: C, 71.53; H, 7.39; N, 6.42; O, 14.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KSCM-1; KSCM 1; KSCM1;

IUPAC/Chemical Name

5,6-Dimethoxy-3-methyl-N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamide

InChi Key

RQJPWNOKFLOHKI-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H32N2O4/c1-19-21-17-23(30-2)24(31-3)18-22(21)32-25(19)26(29)28(20-11-6-4-7-12-20)16-10-15-27-13-8-5-9-14-27/h4,6-7,11-12,17-18H,5,8-10,13-16H2,1-3H3

SMILES Code

O=C(C1=C(C)C2=CC(OC)=C(OC)C=C2O1)N(C3=CC=CC=C3)CCCN4CCCCC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 436.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Marriott KS, Morrison AZ, Moore M, Olubajo O, Stewart LE. Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors. Bioorg Med Chem. 2012 Dec 1;20(23):6856-61. doi: 10.1016/j.bmc.2012.09.044. Epub 2012 Sep 29. PubMed PMID: 23084435; PubMed Central PMCID: PMC3490055. 2: Marriott KS, Prasad M, Thapliyal V, Bose HS. σ-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation. J Pharmacol Exp Ther. 2012 Dec;343(3):578-86. doi: 10.1124/jpet.112.198168. Epub 2012 Aug 24. PubMed PMID: 22923735; PubMed Central PMCID: PMC3500540.