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MedKoo Cat#: 597976 | Name: Polymyxin B2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polymyxin B2 is an antibiotic primarily used for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.

Chemical Structure

Polymyxin B2
Polymyxin B2
CAS#34503-87-2

Theoretical Analysis

MedKoo Cat#: 597976

Name: Polymyxin B2

CAS#: 34503-87-2

Chemical Formula: C55H96N16O13

Exact Mass: 1188.7343

Molecular Weight: 1189.47

Elemental Analysis: C, 55.54; H, 8.14; N, 18.84; O, 17.49

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Polymyxin B2; Polymyxin-B2; PolymyxinB2
IUPAC/Chemical Name
N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methylheptanamide
InChi Key
SGPYLFWAQBAXCZ-RUDZPDEXSA-N
InChi Code
InChI=1S/C55H96N16O13/c1-30(2)12-10-11-15-43(74)62-35(16-22-56)50(79)71-45(33(6)73)55(84)67-38(19-25-59)47(76)66-40-21-27-61-54(83)44(32(5)72)70-51(80)39(20-26-60)64-46(75)36(17-23-57)65-52(81)41(28-31(3)4)68-53(82)42(29-34-13-8-7-9-14-34)69-48(77)37(18-24-58)63-49(40)78/h7-9,13-14,30-33,35-42,44-45,72-73H,10-12,15-29,56-60H2,1-6H3,(H,61,83)(H,62,74)(H,63,78)(H,64,75)(H,65,81)(H,66,76)(H,67,84)(H,68,82)(H,69,77)(H,70,80)(H,71,79)/t32-,33-,35+,36+,37+,38+,39+,40+,41+,42-,44+,45+/m1/s1
SMILES Code
C[C@@H](O)[C@H]1C(NCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCC(C)C)=O)CCN)=O)[C@H](O)C)=O)CCN)=O)C(N[C@@H](CCN)C(N[C@H](Cc2ccccc2)C(N[C@@H](CC(C)C)C(N[C@@H](CCN)C(N[C@@H](CCN)C(N1)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,189.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meng M, Wang L, Liu S, Jaber OM, Gao L, Chevrette L, Reuschel S. Simultaneous quantitation of polymyxin B1, polymyxin B2 and polymyxin B1-1 in human plasma and treated human urine using solid phase extraction and liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:23-36. doi: 10.1016/j.jchromb.2016.01.013. Epub 2016 Jan 12. PubMed PMID: 26803416. 2: Thomas TA, Broun EC, Abildskov KM, Kubin CJ, Horan J, Yin MT, Cremers S. High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma. Ther Drug Monit. 2012 Aug;34(4):398-405. doi: 10.1097/FTD.0b013e31825c827a. PubMed PMID: 22735673; PubMed Central PMCID: PMC3394890. 3: Abodakpi H, Gohlke J, Chang KT, Chow DS, Tam VH. Analytical and functional determination of polymyxin B protein binding in serum. Antimicrob Agents Chemother. 2015 Nov;59(11):7121-3. doi: 10.1128/AAC.01815-15. Epub 2015 Aug 31. PubMed PMID: 26324262; PubMed Central PMCID: PMC4604353. 4: Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE. Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol. 2011 Dec 23;18(12):1640-8. doi: 10.1016/j.chembiol.2011.09.017. PubMed PMID: 22195566. 5: WILKINSON S, LOWE LA. STRUCTURES OF POLYMYXIN B2 AND POLYMYXIN E1. Nature. 1964 Dec 5;204:993-4. PubMed PMID: 14248718. 6: WILKINSON S, LOWE LA. STRUCTURES OF POLYMYXIN B2 AND POLYMYXIN E1. Nature. 1964 Oct 10;204:185. PubMed PMID: 14222268. 7: Hee KH, Leaw YKJ, Ong JL, Lee LS. Development and validation of liquid chromatography tandem mass spectrometry method quantitative determination of polymyxin B1, polymyxin B2, polymyxin B3 and isoleucine-polymyxin B1 in human plasma and its application in clinical studies. J Pharm Biomed Anal. 2017 Jun 5;140:91-97. doi: 10.1016/j.jpba.2017.03.018. Epub 2017 Mar 14. PubMed PMID: 28343078. 8: Covelli J, Ruszaj D, Straubinger R, Li J, Rao GG. The development and validation of a simple liquid chromatography-tandem mass spectrometry method for polymyxin B1 and B2 quantification in different matrices. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 15;1065-1066:112-118. doi: 10.1016/j.jchromb.2017.09.031. Epub 2017 Sep 21. PubMed PMID: 28961485. 9: Sivanesan S, Roberts K, Wang J, Chea SE, Thompson PE, Li J, Nation RL, Velkov T. Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. J Nat Prod. 2017 Jan 27;80(1):225-229. doi: 10.1021/acs.jnatprod.6b01176. Epub 2017 Jan 12. PubMed PMID: 28080060.