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MedKoo Cat#: 597975 | Name: Polymyxin D2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Polymyxin D2 is a cationic lipopeptide antibiotic active against many species of Gram-negative bacteria.

Chemical Structure

Polymyxin D2
Polymyxin D2
CAS#34167-45-8

Theoretical Analysis

MedKoo Cat#: 597975

Name: Polymyxin D2

CAS#: 34167-45-8

Chemical Formula: C49H91N15O15

Exact Mass: 1129.6819

Molecular Weight: 1130.35

Elemental Analysis: C, 52.07; H, 8.11; N, 18.59; O, 21.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Polymyxin D2;
IUPAC/Chemical Name
N-((S)-4-amino-1-(((2S,3R)-3-hydroxy-1-(((R)-3-hydroxy-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3,12-bis((R)-1-hydroxyethyl)-15-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)propan-2-yl)amino)-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methylheptanamide
InChi Key
AMOWTOQDROFIIR-ALESKEBOSA-N
InChi Code
InChI=1S/C49H91N15O15/c1-24(2)10-8-9-11-36(69)55-29(12-17-50)43(73)63-39(28(7)68)49(79)61-35(23-65)46(76)58-33-16-21-54-47(77)37(26(5)66)62-44(74)32(15-20-53)57-40(70)31(14-19-52)59-48(78)38(27(6)67)64-45(75)34(22-25(3)4)60-41(71)30(13-18-51)56-42(33)72/h24-35,37-39,65-68H,8-23,50-53H2,1-7H3,(H,54,77)(H,55,69)(H,56,72)(H,57,70)(H,58,76)(H,59,78)(H,60,71)(H,61,79)(H,62,74)(H,63,73)(H,64,75)/t26-,27-,28-,29+,30+,31+,32+,33+,34-,35-,37+,38+,39+/m1/s1
SMILES Code
C[C@@H](O)[C@H]1C(NCC[C@H](NC([C@H](NC([C@@H](NC([C@@H](NC(CCCCC(C)C)=O)CCN)=O)[C@H](O)C)=O)CO)=O)C(N[C@@H](CCN)C(N[C@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCN)C(N[C@@H](CCN)C(N1)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,130.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shaheen M, Li J, Ross AC, Vederas JC, Jensen SE. Paenibacillus polymyxa PKB1 produces variants of polymyxin B-type antibiotics. Chem Biol. 2011 Dec 23;18(12):1640-8. doi: 10.1016/j.chembiol.2011.09.017. PubMed PMID: 22195566. 2: Gilleland HE Jr, Conrad RS. Chemical alterations in cell envelopes of polymyxin-resistant mutants of Pseudomonas aeruginosa grown in the absence or presence of polymyxin. Antimicrob Agents Chemother. 1982 Dec;22(6):1012-6. PubMed PMID: 6297381; PubMed Central PMCID: PMC185712. 3: Iannazzo L, Sathananthan S, Majewski H. Modulation of dopamine release from rat striatum by protein kinase C: interaction with presynaptic D2-dopamine-autoreceptors. Br J Pharmacol. 1997 Dec;122(8):1561-6. PubMed PMID: 9422799; PubMed Central PMCID: PMC1565103. 4: Jamrozik Z, De Yebenes JG, Troung DD, Cadet J. Intrastriatal infusion of amiloride increases rotations in 6-OHDA lesioned rats and "down-regulates" D2 receptors in the striatum and 5-HT2A receptors in the cortex. Pol J Pharmacol. 1994 Sep-Oct;46(5):417-22. PubMed PMID: 7894528. 5: Ftayeh RM, von Tiedemann A, Rudolph KW. A new selective medium for isolation of Clavibacter michiganensis subsp. michiganensis from tomato plants and seed. Phytopathology. 2011 Nov;101(11):1355-64. doi: 10.1094/PHYTO-02-11-0045. PubMed PMID: 21999159. 6: Wang JP, Hsu MF, Raung SL, Chen CC, Kuo JS, Teng CM. Anti-inflammatory and analgesic effects of magnolol. Naunyn Schmiedebergs Arch Pharmacol. 1992 Dec;346(6):707-12. PubMed PMID: 1336574. 7: Marley SB, Hadley CL, Wakelin D. Effect of genetic variation on induced neutrophilia in mice. Infect Immun. 1994 Oct;62(10):4304-9. PubMed PMID: 7927688; PubMed Central PMCID: PMC303109. 8: Kato T, Shoji T. The structure of octapeptin D (studies on antibiotics from the genus Bacillus. XXVIII). J Antibiot (Tokyo). 1980 Feb;33(2):186-91. PubMed PMID: 7380727. 9: Hu G, Wu YM, Jin GZ. (-)-Stepholidine enhances K+ depolarization-induced activation of synaptosomal tyrosine 3-monooxygenase from rat striatum. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):49-52. PubMed PMID: 10072893. 10: Kapotas NM. Acclimatization resistance of a Pseudomonas aeruginosa prototype strain to imipenem. J Antibiot (Tokyo). 1991 Sep;44(9):985-94. PubMed PMID: 1938622. 11: Kobayashi I, Hasegawa M, Nishida M. [Alteration of serotype and drug susceptibility of some Pseudomonas aeruginosa isolates by exposure to human serum and polymorphonuclear leukocytes]. Kansenshogaku Zasshi. 1994 Apr;68(4):500-7. Japanese. PubMed PMID: 8027598.