Naphthionic acid | CAS#84-86-6 |

MedKoo Cat#: 592260 | Name: Naphthionic acid

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naphthionic acid is a biochemical.

Chemical Structure

Naphthionic acid

CAS#84-86-6

Theoretical Analysis

MedKoo Cat#: 592260

Name: Naphthionic acid

CAS#: 84-86-6

Chemical Formula: C10H9NO3S

Exact Mass: 223.0303

Molecular Weight: 223.25

Elemental Analysis: C, 53.80; H, 4.06; N, 6.27; O, 21.50; S, 14.36

Price and Availability

Size	Price	Availability	Quantity
25g	USD 300.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Naphthionic acid

IUPAC/Chemical Name

1-Naphthalenesulfonic acid, 4-amino-

InChi Key

NRZRRZAVMCAKEP-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9NO3S/c11-9-5-6-10(15(12,13)14)8-4-2-1-3-7(8)9/h1-6H,11H2,(H,12,13,14)

SMILES Code

O=S(C1=C2C=CC=CC2=C(N)C=C1)(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Naphthionic acid is a biochemical.

In vitro activity:

Synthesis of DSNAF was performed by diazotization of 2,7-diaminofluorene in a stream of argon followed by azo coupling with naphthionic acid. It has been demonstrated for the first time that a new fluorene-based analogue of Congo red, DSNAF, can be successfully used to identify amyloid deposits in histological sections of human myocardium. In terms of the specificity and intensity of amyloid staining, DSNAF is comparable to Congo red, which is the gold standard for detecting amyloid deposits. Reference: Sovrem Tekhnologii Med. 2020;12(1):65-70. https://pubmed.ncbi.nlm.nih.gov/34513039/

In vivo activity:

Though AM (amaranth) had been recognized to be non-metabolized in the liver, AM has been reported to be metabolized via azo-reduction by intestinal microflora and/or in the liver to yield naphthionic acid (1-amino-4-naphthalene sulfonic acid) (NSA) after oral administration. In the present investigation, AM was metabolized also in the perfused rat liver to yield NSA, which was not excreted in the bile, but effluxed into the effluent. Reference: J Pharmacobiodyn. 1986 Jul;9(7):570-7. https://pubmed.ncbi.nlm.nih.gov/3772714/

Preparing Stock Solutions

The following data is based on the product molecular weight 223.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Guselnikova VV, Antimonova OI, Fedorova EA, Shavlovsky MM, Safray AE, Rukavishnikova AA, Ilyin VV, Milman BL, Korzhevskii DE. A Novel Method for Amyloid Detection in Human Tissue Load Using a Fluorescent Dye - Congo Red Analogue. Sovrem Tekhnologii Med. 2020;12(1):65-70. doi: 10.17691/stm2020.12.1.08. PMID: 34513039; PMCID: PMC8353706. 2. Lefebvre DE, Ross N, Kocmarek AL, Cowell S, Dai S, Qiao C, Curran I, Koerner T, Bondy GS, Fine JH. In vitro immunomodulation of splenocytes from DO11.10 mice by the food colouring agent amaranth. Food Chem Toxicol. 2017 Dec;110:395-401. doi: 10.1016/j.fct.2017.10.041. Epub 2017 Nov 5. PMID: 29107027. 3. Takahashi K, Higashi Y, Yata N. Hepato-biliary transport of amaranth by single pass liver perfusion in normal and carbon tetrachloride or alpha-naphthylisothiocyanate treated rats. J Pharmacobiodyn. 1986 Jul;9(7):570-7. doi: 10.1248/bpb1978.9.570. PMID: 3772714.

In vitro protocol:

In vivo protocol:

1. Takahashi K, Higashi Y, Yata N. Hepato-biliary transport of amaranth by single pass liver perfusion in normal and carbon tetrachloride or alpha-naphthylisothiocyanate treated rats. J Pharmacobiodyn. 1986 Jul;9(7):570-7. doi: 10.1248/bpb1978.9.570. PMID: 3772714.