Synonym
Demegestone; Lutionex; R 2453; R-2453; R2453; RU 2453; RU-2453; RU2453;
IUPAC/Chemical Name
(8S,13S,14S,17S)-17-acetyl-13,17-dimethyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
JWAHBTQSSMYISL-MHTWAQMVSA-N
InChi Code
InChI=1S/C21H28O2/c1-13(22)20(2)11-9-19-18-6-4-14-12-15(23)5-7-16(14)17(18)8-10-21(19,20)3/h12,18-19H,4-11H2,1-3H3/t18-,19+,20-,21+/m1/s1
SMILES Code
CC([C@@]1(C)CC[C@@]2([H])[C@]3([H])CCC4=CC(CCC4=C3CC[C@]12C)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.45
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Pugeat M, Lejeune H, Dechaud H, Brébant C, Mallein R, Tourniaire J. [Luteal insufficiency and elevation of sex-binding proteins by demegestone]. Rev Fr Gynecol Obstet. 1988 Jul-Sep;83(7-9):495-8. French. PubMed PMID: 3194612.
2: Prost-Avallet O, Oursin J, Adessi GL. In vitro effect of synthetic progestogens on estrone sulfatase activity in human breast carcinoma. J Steroid Biochem Mol Biol. 1991 Dec;39(6):967-73. PubMed PMID: 1751397.
3: Martin PM, Rolland PH, Gammerre M, Serment H. [OEstradiol and progesterone steroid hormone receptors in cancer of the endometrium. The significance of the progesterone receptor (author's transl)]. J Gynecol Obstet Biol Reprod (Paris). 1979;8(8):681-4. French. PubMed PMID: 553927.
4: Gicquel A. [Treatment of early menopause. A report of 2 cases]. Sem Hop. 1983 Jan 6;59(1):47-8. French. PubMed PMID: 6297087.
5: Pugeat M, Elmidani M, Dechaud H, Garoscio-Cholet M, Lejeune H, Tourniaire J. [Treatment of hirsutism with spironolactone and progestagen combination]. Presse Med. 1990 Oct 13;19(33):1529-32. French. PubMed PMID: 2146664.
6: Aguilar-Martinez P, Montoya F, Montoya P, Laffargue F, Viala JL. [Male pseudo-hermaphroditism. Prenatal factors]. J Gynecol Obstet Biol Reprod (Paris). 1990;19(3):285-9. French. PubMed PMID: 2345270.
