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MedKoo Cat#: 597922 | Name: Krds peptide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Krds peptide is a synthetic tetrapeptide derived from lactotransferrin (residues 39 to 42); inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-Stimulated platelets and megakaryocytes.

Chemical Structure

Krds peptide
Krds peptide
CAS#116430-80-9

Theoretical Analysis

MedKoo Cat#: 597922

Name: Krds peptide

CAS#: 116430-80-9

Chemical Formula: C19H36N8O8

Exact Mass: 504.2656

Molecular Weight: 504.54

Elemental Analysis: C, 45.23; H, 7.19; N, 22.21; O, 25.37

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Krds peptide; Lys-arg-asp-ser;
IUPAC/Chemical Name
(S)-4-(((S)-1-carboxy-2-hydroxyethyl)amino)-3-((S)-2-((S)-2,6-diaminohexanamido)-5-guanidinopentanamido)-4-oxobutanoic acid
InChi Key
UIQDLWNRJRTKJV-CYDGBPFRSA-N
InChi Code
InChI=1S/C19H36N8O8/c20-6-2-1-4-10(21)15(31)25-11(5-3-7-24-19(22)23)16(32)26-12(8-14(29)30)17(33)27-13(9-28)18(34)35/h10-13,28H,1-9,20-21H2,(H,25,31)(H,26,32)(H,27,33)(H,29,30)(H,34,35)(H4,22,23,24)/t10-,11-,12-,13-/m0/s1
SMILES Code
OC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)N)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 504.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lévy-Toledano S, Grelac F, Caen JP, Maclouf J. KRDS, a peptide derived from human lactotransferrin, inhibits thrombin-induced thromboxane synthesis by a cyclooxygenase-independent mechanism. Thromb Haemost. 1995 May;73(5):857-61. PubMed PMID: 7482416. 2: Mazoyer E, Lévy-Toledano S, Rendu F, Hermant L, Lu H, Fiat AM, Jollès P, Caen J. KRDS, a new peptide derived from human lactotransferrin, inhibits platelet aggregation and release reaction. Eur J Biochem. 1990 Nov 26;194(1):43-9. PubMed PMID: 2174781. 3: Wu G, Ruan C, Drouet L, Caen J. Inhibition effects of KRDS, a peptide derived from lactotransferrin, on platelet function and arterial thrombus formation in dogs. Haemostasis. 1992;22(1):1-6. PubMed PMID: 1381697. 4: Drouet L, Bal dit Sollier C, Cisse M, Pignaud G, Mazoyer E, Fiat AM, Jolles P, Caen JP. The antithrombotic effect of KRDS, a lactotransferrin peptide, compared with RGDS. Nouv Rev Fr Hematol. 1990;32(1):59-62. PubMed PMID: 2349083. 5: Raha S, Dosquet C, Abgrall JF, Jolles P, Fiat AM, Caen JP. KRDS--a tetrapeptide derived from lactotransferrin--inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-stimulated platelets and megakaryocytes. Blood. 1988 Jul;72(1):172-8. PubMed PMID: 3291978. 6: Kumar DA, Manikandan P, Sumitra M, Raju KV, Gayathri C, Arutselvan N, Puvanakrishnan R. A novel peptide derivative exhibits anti inflammatory and antioxidant activity in adjuvant induced arthritis in rats. Mol Cell Biochem. 2002 Jan;229(1-2):9-17. PubMed PMID: 11936851. 7: Ahmed MR, Basha SH, Gopinath D, Muthusamy R, Jayakumar R. Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide-incorporated collagen tubes. J Peripher Nerv Syst. 2005 Mar;10(1):17-30. PubMed PMID: 15703015. 8: Meddeb S, Demaret JP, Ballini JP, Fiat AM, Jollès P, Ptak M, Vigny P. A conformational study of Lys-Arg-Asp-Ser and analogs, a series of potent antithrombotic peptides. An approach based on simulated annealing and 1H NMR. J Biomol Struct Dyn. 1994 Apr;11(5):959-81. PubMed PMID: 7946066. 9: Kumar DA, Settu K, Raju KV, Kumanan K, Manohar BM, Puvanakrishnan R. Inhibition of nitric oxide and caspase-3 mediated apoptosis by a tetrapeptide derivative (PEP1261) in cultured synovial fibroblasts from collagen-induced arthritis. Mol Cell Biochem. 2006 Jan;282(1-2):125-39. PubMed PMID: 16317520. 10: Ramesh CV, Malarvannan P, Jayakumar R, Jayasundar S, Puvanakrishnan R. Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. Mol Cell Biochem. 1998 Oct;187(1-2):173-82. PubMed PMID: 9788755.