Synonym
Sermetacin; SH G 318 AB; SHG 318 AB; TVX 3158; Sermetacina;
IUPAC/Chemical Name
(2-(1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)acetyl)-L-serine
InChi Key
AUDFHJLSHQWFQQ-SFHVURJKSA-N
InChi Code
InChI=1S/C22H21ClN2O6/c1-12-16(10-20(27)24-18(11-26)22(29)30)17-9-15(31-2)7-8-19(17)25(12)21(28)13-3-5-14(23)6-4-13/h3-9,18,26H,10-11H2,1-2H3,(H,24,27)(H,29,30)/t18-/m0/s1
SMILES Code
OC[C@@H](C(O)=O)NC(CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
444.86
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Tang ZZ, Lin DY. Meta-analysis for Discovering Rare-Variant Associations: Statistical Methods and Software Programs. Am J Hum Genet. 2015 Jul 2;97(1):35-53. doi: 10.1016/j.ajhg.2015.05.001. Epub 2015 Jun 18. PubMed PMID: 26094574; PubMed Central PMCID: PMC4571037.
2: Tang ZZ, Bunn P, Tao R, Liu Z, Lin DY. PreMeta: a tool to facilitate meta-analysis of rare-variant associations. BMC Genomics. 2017 Feb 14;18(1):160. doi: 10.1186/s12864-017-3573-1. PubMed PMID: 28196472; PubMed Central PMCID: PMC5310051.
3: Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH Jr. Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. PLoS One. 2017 Jul 13;12(7):e0180046. doi: 10.1371/journal.pone.0180046. eCollection 2017. PubMed PMID: 28704393; PubMed Central PMCID: PMC5509141.
4: Sabo A, Mishra P, Dugan-Perez S, Voruganti VS, Kent JW Jr, Kalra D, Cole SA, Comuzzie AG, Muzny DM, Gibbs RA, Butte NF. Exome sequencing reveals novel genetic loci influencing obesity-related traits in Hispanic children. Obesity (Silver Spring). 2017 Jul;25(7):1270-1276. doi: 10.1002/oby.21869. Epub 2017 May 16. PubMed PMID: 28508493; PubMed Central PMCID: PMC5687071.