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MedKoo Cat#: 597913 | Name: Thrazarine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thrazarine is a new antitumor antibiotic produced by Streptomyces coerulescens MH802-fF5.

Chemical Structure

Thrazarine
Thrazarine
CAS#120128-14-5

Theoretical Analysis

MedKoo Cat#: 597913

Name: Thrazarine

CAS#: 120128-14-5

Chemical Formula: C7H11N3O5

Exact Mass: 217.0699

Molecular Weight: 217.18

Elemental Analysis: C, 38.71; H, 5.11; N, 19.35; O, 36.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Thrazarine;
IUPAC/Chemical Name
O-((R)-2-diazo-3-hydroxybutanoyl)-L-serine
InChi Key
WAKGSHQRLIGGLB-DMTCNVIQSA-N
InChi Code
InChI=1S/C7H11N3O5/c1-3(11)5(10-9)7(14)15-2-4(8)6(12)13/h3-4,11H,2,8H2,1H3,(H,12,13)/t3-,4+/m1/s1
SMILES Code
N[C@@H](COC(C([C@H](O)C)=[N+]=[N-])=O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 217.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kameyama T, Takahashi A, Matsumoto H, Kurasawa S, Hamada M, Okami Y, Ishizuka M, Takeuchi T. Thrazarine, a new antitumor antibiotic. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1988 Nov;41(11):1561-7. PubMed PMID: 3143704. 2: Takahashi A, Nakamura H, Ikeda D, Naganawa H, Kameyama T, Kurasawa S, Okami Y, Takeuchi T, Iitaka Y. Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination. J Antibiot (Tokyo). 1988 Nov;41(11):1568-74. PubMed PMID: 3143705. 3: Nishimura M, Nakada H, Takase S, Katayama A, Goto T, Tanaka H, Hashimoto M. A new antitumor antibiotic, FR900840. II. Structural elucidation of FR900840. J Antibiot (Tokyo). 1989 Apr;42(4):549-52. PubMed PMID: 2498270. 4: Nishimura M, Nakada H, Nakajima H, Hori Y, Ezaki M, Goto T, Okuhara M. A new antitumor antibiotic, FR900840. I. Discovery, identification, isolation and characterization. J Antibiot (Tokyo). 1989 Apr;42(4):542-8. PubMed PMID: 2498269. 5: Nishimura M, Nakada H, Kawamura I, Mizota T, Shimomura K, Nakahara K, Goto T, Yamaguchi I, Okuhara M. A new antitumor antibiotic, FR900840. III. Antitumor activity against experimental tumors. J Antibiot (Tokyo). 1989 Apr;42(4):553-7. PubMed PMID: 2542208.