MedKoo Cat#: 592246 | Name: Tolazoline hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolazoline hydrochloride is a vasodilator that increases cardiac output. Tolazoline interacts with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.

Chemical Structure

Tolazoline hydrochloride
CAS#59-97-2

Theoretical Analysis

MedKoo Cat#: 592246

Name: Tolazoline hydrochloride

CAS#: 59-97-2

Chemical Formula: C10H13ClN2

Exact Mass: 196.0767

Molecular Weight: 196.68

Elemental Analysis: C, 61.07; H, 6.66; Cl, 18.02; N, 14.24

Price and Availability

Size Price Availability Quantity
5g USD 200.00
25g USD 315.00
100g USD 515.00
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Related CAS #
No Data
Synonym
AI3-52042, Arterodyl, Benzazoline hydrochloride, Benzylimidazoline hydrochloride, Benzylimidazoline HCl, Imidaline hydrochloride, Imidaline HCl, Priscoline hydrochloride, Priscoline HCl, Tolavad, Tolazoline hydrochloride, Tolazoline HCl, Tolpal
IUPAC/Chemical Name
1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, hydrochloride (1:1)
InChi Key
RHTNTTODYGNRSP-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12N2.ClH/c1-2-4-9(5-3-1)8-10-11-6-7-12-10;/h1-5H,6-8H2,(H,11,12);1H
SMILES Code
[H]Cl.C1(CC2=CC=CC=C2)=NCCN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 196.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Loeppky RN, Shi J, Barnes CL, Geddam S. A diazonium ion cascade from the nitrosation of tolazoline, an imidazoline-containing drug. Chem Res Toxicol. 2008 Feb;21(2):295-307. doi: 10.1021/tx700317g. Epub 2008 Feb 2. PubMed PMID: 18247523. 2: Huwer H, Winning J, Straub U, Isringhaus H, Kalweit G. Clinically diagnosed nonocclusive mesenteric ischemia after cardiopulmonary bypass: retrospective study. Vascular. 2004 Mar;12(2):114-20. PubMed PMID: 15248641. 3: Molderings GJ, Schmidt K, Bönisch H, Göthert M. Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sites. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):245-52. PubMed PMID: 8878053. 4: Hung HY, Huang FY, Ho MY, Kao HA. Adult respiratory distress syndrome in full term neonates. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1994 Jan-Feb;35(1):36-44. PubMed PMID: 8178641. 5: Bos AP, Tibboel D, Koot VC, Hazebroek FW, Molenaar JC. Persistent pulmonary hypertension in high-risk congenital diaphragmatic hernia patients: incidence and vasodilator therapy. J Pediatr Surg. 1993 Nov;28(11):1463-5. PubMed PMID: 8301459. 6: Yamaki S, Yasui H, Kado H, Yonenaga K, Nakamura Y, Kikuchi T, Ajiki H, Tsunemoto M, Mohri H. Pulmonary vascular disease and operative indications in complete atrioventricular canal defect in early infancy. J Thorac Cardiovasc Surg. 1993 Sep;106(3):398-405. PubMed PMID: 8361179. 7: Angeles DM. Pathophysiology and nursing management of persistent pulmonary hypertension of the newborn. MCN Am J Matern Child Nurs. 1992 Nov-Dec;17(6):314-21. Review. PubMed PMID: 1435120. 8: Hopkins RA, Bull C, Haworth SG, de Leval MR, Stark J. Pulmonary hypertensive crises following surgery for congenital heart defects in young children. Eur J Cardiothorac Surg. 1991;5(12):628-34. PubMed PMID: 1772678.