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MedKoo Cat#: 597908 | Name: Foroxymithine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Foroxymithine is an angiotensin-converting enzyme inhibitor.

Chemical Structure

Foroxymithine
Foroxymithine
CAS#100157-28-6

Theoretical Analysis

MedKoo Cat#: 597908

Name: Foroxymithine

CAS#: 100157-28-6

Chemical Formula: C22H41N7O13

Exact Mass: 611.2762

Molecular Weight: 611.60

Elemental Analysis: C, 43.20; H, 6.76; N, 16.03; O, 34.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Foroxymithine; Foroxymithine dihydrate;
IUPAC/Chemical Name
(S)-2-acetamido-N-(N-hydroxy-N-(3-((2R,5R)-5-(3-(N-hydroxyformamido)propyl)-3,6-dioxopiperazin-2-yl)propyl)-L-seryl)-5-(N-hydroxyformamido)pentanamide dihydrate
InChi Key
QCGPPCVYSABUPR-KNEROFGVSA-N
InChi Code
InChI=1S/C22H37N7O11.2H2O/c1-14(33)23-15(5-2-8-27(38)12-31)21(36)26-22(37)18(11-30)29(40)10-4-7-17-20(35)24-16(19(34)25-17)6-3-9-28(39)13-32;;/h12-13,15-18,30,38-40H,2-11H2,1H3,(H,23,33)(H,24,35)(H,25,34)(H,26,36,37);2*1H2/t15-,16+,17+,18-;;/m0../s1
SMILES Code
OC[C@@H](C(NC([C@H](CCCN(C=O)O)NC(C)=O)=O)=O)N(CCC[C@H](C(N[C@@H]1CCCN(C=O)O)=O)NC1=O)O.[H]O[H].[H]O[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 611.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kodani S, Komaki H, Suzuki M, Kobayakawa F, Hemmi H. Structure determination of a siderophore peucechelin from Streptomyces peucetius. Biometals. 2015 Oct;28(5):791-801. doi: 10.1007/s10534-015-9866-4. Epub 2015 Jun 18. PubMed PMID: 26085470. 2: Aoyagi T, Wada T, Iinuma H, Ogawa K, Kojima F, Nagai M, Kuroda H, Obayashi A, Umezawa H. Influence of angiotensin-converting enzyme inhibitor, foroxymithine, on dynamic equilibrium around the renin-angiotensin system in vivo. J Appl Biochem. 1985 Dec;7(6):388-95. PubMed PMID: 3007425. 3: Imoto M, Umezawa K, Komuro K, Sawa T, Takeuchi T, Umezawa H. Antitumor activity of erbstatin, a tyrosine protein kinase inhibitor. Jpn J Cancer Res. 1987 Apr;78(4):329-32. PubMed PMID: 3108212. 4: Umezawa H, Aoyagi T, Ogawa K, Obata T, Iinuma H, Naganawa H, Hamada M, Takeuchi T. Foroxymithine, a new inhibitor of angiotensin-converting enzyme, produced by actinomycetes. J Antibiot (Tokyo). 1985 Dec;38(12):1813-5. PubMed PMID: 3005216. 5: Wada T, Aoyagi T, Iinuma H, Ogawa K, Kojima F, Nagai M, Kuroda H, Obayashi A, Takeuchi T. Feedback analysis of the behavior of the renin-angiotensin system under inhibition of angiotensin-converting enzyme. Biotechnol Appl Biochem. 1988 Oct;10(5):435-46. PubMed PMID: 3058152. 6: Toi M, Mukaida H, Wada T, Hirabayashi N, Toge T, Hori T, Umezawa K. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26(6):722-4. PubMed PMID: 2144161. 7: Wada T, Aoyagi T. Demonstration of in vivo effects of ACE inhibitors by the use of autoregressive modelling. Adv Exp Med Biol. 1989;247A:191-5. PubMed PMID: 2557740. 8: Tsutsumi N, Nagata H, Arai N, Kojima M, Ujiie A. [Effects of protease inhibitors and protein synthesis inhibitors on cartilage tissue-dependent bone resorption]. Nihon Yakurigaku Zasshi. 1993 Jun;101(6):385-91. Japanese. PubMed PMID: 8340023.