IMM-02 is an inhibitor of DID-DAD binding. IMM02 was superior to antagonism (SMIFH2) as anti-invasion strategies in GBM spheroids. IMM02-mediated mDia agonism disrupts invasion in GBM patient-derived spheroid models, in part by inducing mDia expression loss and tumor microtube network collapse. Pharmacological disruption of ROCK prevented invasive cell-body movement away from GBM spheres, yet induced ultralong, phenotypically abnormal tumor microtube formation. Simultaneously targeting mDia and ROCK did not enhance the anti-invasive/-tumor microtube effects of IMM02.
MedKoo Cat#: 563310
Name: IMM-02
CAS#: 218929-99-8
Chemical Formula: C13H17F2N3OS
Exact Mass: 301.1060
Molecular Weight: 301.35
Elemental Analysis: C, 51.81; H, 5.69; F, 12.61; N, 13.94; O, 5.31; S, 10.64
The following data is based on the product molecular weight 301.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
