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MedKoo Cat#: 597892 | Name: APO-501

Description:

WARNING: This product is for research use only, not for human or veterinary use.

APO-501 is a bioactive chemical.

Chemical Structure

APO-501
APO-501
CAS#242487-05-4

Theoretical Analysis

MedKoo Cat#: 597892

Name: APO-501

CAS#: 242487-05-4

Chemical Formula: C14H22N4O4S

Exact Mass: 342.1362

Molecular Weight: 342.41

Elemental Analysis: C, 49.11; H, 6.48; N, 16.36; O, 18.69; S, 9.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
APO-501; APO501; APO 501;
IUPAC/Chemical Name
(3-methoxy-1,2,4-thiadiazol-5-yl)-L-leucyl-L-proline
InChi Key
NLRGTDIOUKAAHH-UWVGGRQHSA-N
InChi Code
InChI=1S/C14H22N4O4S/c1-8(2)7-9(15-14-16-13(22-3)17-23-14)11(19)18-6-4-5-10(18)12(20)21/h8-10H,4-7H2,1-3H3,(H,20,21)(H,15,16,17)/t9-,10-/m0/s1
SMILES Code
O=C(O)[C@H]1N(C([C@H](CC(C)C)NC2=NC(OC)=NS2)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hara H, Maeda A, Kamiya T, Adachi T. Protective effects of apomorphine against zinc-induced neurotoxicity in cultured cortical neurons. Biol Pharm Bull. 2013;36(4):585-91. PubMed PMID: 23546293. 2: Byrne DP, Manandhar SP, Potempa J, Smalley JW. Breakdown of albumin and haemalbumin by the cysteine protease interpain A, an albuminase of Prevotella intermedia. BMC Microbiol. 2015 Sep 24;15:185. doi: 10.1186/s12866-015-0516-3. PubMed PMID: 26403890; PubMed Central PMCID: PMC4582931. 3: Harwood DG, Barker WW, Ownby RL, St George-Hyslop P, Duara R. Apolipoprotein-E (APO-E) genotype and symptoms of psychosis in Alzheimer's disease. Am J Geriatr Psychiatry. 1999 Spring;7(2):119-23. PubMed PMID: 10322238. 4: Cho S, Moon H, Loh TJ, Jang HN, Liu Y, Zhou J, Ohn T, Zheng X, Shen H. Splicing inhibition of U2AF65 leads to alternative exon skipping. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9926-31. doi: 10.1073/pnas.1500639112. Epub 2015 Jul 27. PubMed PMID: 26216990; PubMed Central PMCID: PMC4538632. 5: Olszynski WP, Adachi JD, Davison KS. Differences in In Vitro Disintegration Time among Canadian Brand and Generic Bisphosphonates. J Osteoporos. 2014;2014:420451. doi: 10.1155/2014/420451. Epub 2014 Oct 2. PubMed PMID: 25349772; PubMed Central PMCID: PMC4202245. 6: Kiema TR, Harijan RK, Strozyk M, Fukao T, Alexson SE, Wierenga RK. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3212-25. doi: 10.1107/S1399004714023827. Epub 2014 Nov 22. PubMed PMID: 25478839. 7: Koren-Morag N, Goldbourt U, Graff E, Tanne D. Apolipoproteins B and AI and the risk of ischemic cerebrovascular events in patients with pre-existing atherothrombotic disease. J Neurol Sci. 2008 Jul 15;270(1-2):82-7. doi: 10.1016/j.jns.2008.02.005. Epub 2008 Apr 2. PubMed PMID: 18377938. 8: Gerner L, Munack S, Temmerman K, Lawrence-Dörner AM, Besir H, Wilmanns M, Jensen JK, Thiede B, Mills IG, Morth JP. Data for the co-expression and purification of human recombinant CaMKK2 in complex with calmodulin in Escherichia coli. Data Brief. 2016 Jun 29;8:733-40. doi: 10.1016/j.dib.2016.06.033. eCollection 2016 Sep. PubMed PMID: 27508226; PubMed Central PMCID: PMC4950174. 9: Gupta AK, Ross EA, Myers JN, Kashyap ML. Increased reverse cholesterol transport in athletes. Metabolism. 1993 Jun;42(6):684-90. PubMed PMID: 8510511. 10: LeBlanc AC, Poduslo JF. Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve. J Neurosci Res. 1990 Feb;25(2):162-71. PubMed PMID: 2319626. 11: Ruixing Y, Shangling P, Hong C, Hanjun Y, Hai W, Yuming C, Jinzhen W, Feng H, Meng L, Muyan L. Diet, alcohol consumption, and serum lipid levels of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations. Alcohol. 2008 May;42(3):219-29. doi: 10.1016/j.alcohol.2008.01.009. PubMed PMID: 18420116. 12: Lian S, Xia Y, Khoi PN, Ung TT, Yoon HJ, Kim NH, Kim KK, Jung YD. Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology. 2015 Dec 2;338:104-16. doi: 10.1016/j.tox.2015.10.008. Epub 2015 Nov 11. PubMed PMID: 26514923. 13: van het Schip AD, Meijlink FC, Strijker R, Gruber M, van Vliet AJ, van de Klundert JA, Ab G. The nucleotide sequence of the chicken apo very low density lipoprotein II gene. Nucleic Acids Res. 1983 May 11;11(9):2529-40. PubMed PMID: 6856469; PubMed Central PMCID: PMC325905. 14: Suzuki M, Wada H, Maeda S, Saito K, Minatoguchi S, Saito K, Seishima M. Increased plasma lipid-poor apolipoprotein A-I in patients with coronary artery disease. Clin Chem. 2005 Jan;51(1):132-7. Epub 2004 Nov 18. PubMed PMID: 15550473. 15: Tanaka T, Oyama T, Sugie S, Shimizu M. Different Susceptibilities between Apoe- and Ldlr-Deficient Mice to Inflammation-Associated Colorectal Carcinogenesis. Int J Mol Sci. 2016 Oct 28;17(11). pii: E1806. PubMed PMID: 27801847; PubMed Central PMCID: PMC5133807. 16: Everett BM, Glynn RJ, Buring JE, Ridker PM. Lipid biomarkers, hormone therapy and the risk of venous thromboembolism in women. J Thromb Haemost. 2009 Apr;7(4):588-96. doi: 10.1111/j.1538-7836.2009.03302.x. Epub 2009 Jan 24. PubMed PMID: 19187075; PubMed Central PMCID: PMC2694669. 17: Niranjan R. Molecular basis of etiological implications in Alzheimer's disease: focus on neuroinflammation. Mol Neurobiol. 2013 Dec;48(3):412-28. doi: 10.1007/s12035-013-8428-4. Epub 2013 Feb 19. Review. PubMed PMID: 23420079. 18: Porck HJ, Fràter-Schröder M, Frants RR, Kierat L, Eriksson AW. Genetic evidence for fetal origin of transcobalamin II in human cord blood. Blood. 1983 Jul;62(1):234-7. PubMed PMID: 6860794. 19: Toscano CF, Lahlou S. Blood pressure effects of intravenous apomorphine in conscious deoxycorticosterone-acetate salt-hypertensive rats. J Cardiovasc Pharmacol. 2003 Dec;42(6):772-81. PubMed PMID: 14639100. 20: Idzior-Waluś B, Sieradzki J, Kostner G, Małecki MT, Klupa T, Wesołowska T, Rostworowski W, Hartwich J, Waluś M, Kieć AD, Naruszewicz M. Familial lecithin-cholesterol acyltransferase deficiency: biochemical characteristics and molecular analysis of a new LCAT mutation in a Polish family. Atherosclerosis. 2006 Apr;185(2):413-20. Epub 2005 Jul 26. PubMed PMID: 16051254.