Synonym
Crilvastatin; PMD 387; PMD-387; PMD387;
IUPAC/Chemical Name
3,3,5-trimethylcyclohexyl (2S)-5-oxopyrrolidine-2-carboxylate
InChi Key
FXAAOALUHHXBSO-ILDUYXDCSA-N
InChi Code
InChI=1S/C14H23NO3/c1-9-6-10(8-14(2,3)7-9)18-13(17)11-4-5-12(16)15-11/h9-11H,4-8H2,1-3H3,(H,15,16)/t9?,10?,11-/m0/s1
SMILES Code
O=C(OC1CC(C)(C)CC(C)C1)[C@H](CC2)NC2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
253.34
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hajri T, Chanussot F, Férézou J, Riottot M, Lafont H, Laruelle C, Lutton C. Reduced cholesterol absorption in hamsters by crilvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor. Eur J Pharmacol. 1997 Feb 5;320(1):65-71. PubMed PMID: 9049604.
2: Clerc T, Jomier M, Chautan M, Portugal H, Senft M, Pauli AM, Laruelle C, Morel O, Lafont H, Chanussot F. Mechanisms of action in the liver of crilvastatin, a new hydroxymethylglutaryl-coenzyme A reductase inhibitor. Eur J Pharmacol. 1993 Apr 22;235(1):59-68. PubMed PMID: 8519281.
3: Clerc T, Sbarra V, Diaconescu N, Lafont H, Jadot G, Laruelle C, Chanussot F. Effect of crilvastatin, a new cholesterol lowering agent, on unesterified LDL-cholesterol metabolism into bile salts by rat isolated hepatocytes. Br J Pharmacol. 1995 Feb;114(3):624-31. PubMed PMID: 7735689; PubMed Central PMCID: PMC1510015.
4: Hajri T, Férézou J, Laruelle C, Lutton C. Crilvastatin, a new 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, inhibits cholesterol absorption in genetically hypercholesterolemic rats. Eur J Pharmacol. 1995 Nov 14;286(2):131-6. PubMed PMID: 8605949.
5: Clerc T, Sbarra V, Domingo N, Rault JP, Diaconescu N, Moutardier V, Hasselot N, Lafont H, Jadot G, Laruelle C, Chanussot F. Differences in hypolipidaemic effects of two statins on Hep G2 cells or human hepatocytes in primary culture. Br J Pharmacol. 1996 Aug;118(7):1862-8. PubMed PMID: 8842455; PubMed Central PMCID: PMC1909841.
