Synonym
AI3-51508; AI3 51508; AI351508; TEMPO
IUPAC/Chemical Name
1-Piperidinyloxy, 2,2,6,6-tetramethyl- (9CI)
InChi Key
QYTDEUPAUMOIOP-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H18NO/c1-8(2)6-5-7-9(3,4)10(8)11/h5-7H2,1-4H3
SMILES Code
[O]N1C(C)(C)CCCC1(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
156.25
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liu S, Liang H, Sun T, Yang D, Cao M. A recoverable dendritic polyamidoamine immobilized TEMPO for efficient catalytic oxidation of cellulose. Carbohydr Polym. 2018 Dec 15;202:563-570. doi: 10.1016/j.carbpol.2018.09.016. Epub 2018 Sep 13. PubMed PMID: 30287037.
2: Guo X, Seo JE, Bryce SM, Tan JA, Wu Q, Dial SL, Moore MM, Mei N. Comparative Genotoxicity of TEMPO and 3 of Its Derivatives in Mouse Lymphoma Cells. Toxicol Sci. 2018 May 1;163(1):214-225. doi: 10.1093/toxsci/kfy022. PubMed PMID: 29385624; PubMed Central PMCID: PMC6388407.
3: Zhou Y, Saito T, Bergström L, Isogai A. Acid-Free Preparation of Cellulose Nanocrystals by TEMPO Oxidation and Subsequent Cavitation. Biomacromolecules. 2018 Feb 12;19(2):633-639. doi: 10.1021/acs.biomac.7b01730. Epub 2018 Jan 16. PubMed PMID: 29283555.
4: Li J, Zhang J, Chen Y, Kawazoe N, Chen G. TEMPO-Conjugated Gold Nanoparticles for Reactive Oxygen Species Scavenging and Regulation of Stem Cell Differentiation. ACS Appl Mater Interfaces. 2017 Oct 18;9(41):35683-35692. doi: 10.1021/acsami.7b12486. Epub 2017 Oct 4. PubMed PMID: 28944661.
5: Fu Q, Sutherland A, Gustafsson E, Ali MM, Soleymani L, Pelton R. Relating Redox Properties of Polyvinylamine-g-TEMPO/Laccase Hydrogel Complexes to Cellulose Oxidation. Langmuir. 2017 Aug 15;33(32):7854-7861. doi: 10.1021/acs.langmuir.7b01460. Epub 2017 Aug 3. PubMed PMID: 28732155.
6: Spier VC, Sierakowski MR, Reed WF, de Freitas RA. Polysaccharide depolymerization from TEMPO-catalysis: Effect of TEMPO concentration. Carbohydr Polym. 2017 Aug 15;170:140-147. doi: 10.1016/j.carbpol.2017.04.064. Epub 2017 Apr 26. PubMed PMID: 28521979.
7: Jiang J, Ye W, Liu L, Wang Z, Fan Y, Saito T, Isogai A. Cellulose Nanofibers Prepared Using the TEMPO/Laccase/O(2) System. Biomacromolecules. 2017 Jan 9;18(1):288-294. doi: 10.1021/acs.biomac.6b01682. Epub 2016 Dec 20. PubMed PMID: 27995786.
8: Du K, Farhood A, Jaeschke H. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Arch Toxicol. 2017 Feb;91(2):761-773. doi: 10.1007/s00204-016-1692-0. Epub 2016 Mar 22. PubMed PMID: 27002509; PubMed Central PMCID: PMC5033665.
