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MedKoo Cat#: 597837 | Name: Amythiamicin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amythiamicin B is a novel antimicrobial antibiotic.

Chemical Structure

Amythiamicin B
Amythiamicin B
CAS#156620-48-3

Theoretical Analysis

MedKoo Cat#: 597837

Name: Amythiamicin B

CAS#: 156620-48-3

Chemical Formula: C50H53N15O9S6

Exact Mass: 1199.2475

Molecular Weight: 1200.43

Elemental Analysis: C, 50.03; H, 4.45; N, 17.50; O, 11.99; S, 16.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Amythiamicin B;
IUPAC/Chemical Name
N-((S)-1-((R)-2-carbamoylpyrrolidin-1-yl)-3-hydroxy-1-oxopropan-2-yl)-2-((12Z,22Z,42Z,82Z,122Z,7R,11R,18R)-11,18-diisopropyl-85-methyl-7-(2-(methylamino)-2-oxoethyl)-5,9,13,16-tetraoxo-6,10,14,17-tetraaza-1(4,2),2,4,8,12(2,4)-pentathiazola-3(2,3)-piperidinacyclooctadecaphane-36-yl)thiazole-4-carboxamide
InChi Key
ZVLJONLPGJUTCW-DTMJCZKRSA-N
InChi Code
InChI=1S/C50H53N15O9S6/c1-20(2)35-48-61-31(19-79-48)46-57-27(15-76-46)38-23(9-10-24(54-38)45-59-30(18-77-45)42(72)56-26(14-66)50(74)65-11-7-8-32(65)39(51)69)44-58-29(17-75-44)41(71)55-25(12-33(67)52-6)47-64-37(22(5)80-47)43(73)63-36(21(3)4)49-60-28(16-78-49)40(70)53-13-34(68)62-35/h9-10,15-21,25-26,32,35-36,66H,7-8,11-14H2,1-6H3,(H2,51,69)(H,52,67)(H,53,70)(H,55,71)(H,56,72)(H,62,68)(H,63,73)/t25-,26+,32-,35-,36-/m1/s1
SMILES Code
Cc1c(C(N[C@H](C(C)C)c2nc(C(NCC(N[C@H](C(C)C)c3nc4cs3)=O)=O)cs2)=O)nc([C@@H](CC(NC)=O)NC(c5nc(c6ccc(c7scc(C(N[C@@H](CO)C(N8CCC[C@@H]8C(N)=O)=O)=O)n7)nc6c9nc4sc9)sc5)=O)s1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,200.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shimanaka K, Takahashi Y, Iinuma H, Naganawa H, Takeuchi T. Novel antibiotics, amythiamicins. III. Structure elucidations of amythiamicins A, B and C. J Antibiot (Tokyo). 1994 Oct;47(10):1153-9. PubMed PMID: 7961166. 2: Nicolaou KC, Dethe DH, Chen DY. Total syntheses of amythiamicins A, B and C. Chem Commun (Camb). 2008 Jun 21;(23):2632-4. doi: 10.1039/b805069b. Epub 2008 May 8. PubMed PMID: 18535690. 3: Shimanaka K, Kinoshita N, Iinuma H, Hamada M, Takeuchi T. Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity. J Antibiot (Tokyo). 1994 Jun;47(6):668-74. PubMed PMID: 8040071.