MedKoo Cat#: 563283 | Name: L-651392

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-651392 is a leukotriene inhibitor.

Chemical Structure

L-651392
L-651392
CAS#93211-49-5

Theoretical Analysis

MedKoo Cat#: 563283

Name: L-651392

CAS#: 93211-49-5

Chemical Formula: C14H10BrNO3S

Exact Mass: 350.9565

Molecular Weight: 352.20

Elemental Analysis: C, 47.74; H, 2.86; Br, 22.69; N, 3.98; O, 13.63; S, 9.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
L-651392; L 651392; L651392;
IUPAC/Chemical Name
4-Bromo-2,7-dimethoxyphenothiazin-3-one
InChi Key
YADZEEVOBOJZRG-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H10BrNO3S/c1-18-7-3-4-8-11(5-7)20-14-9(16-8)6-10(19-2)13(17)12(14)15/h3-6H,1-2H3
SMILES Code
O=C1C(OC)=CC2=NC3=C(C=C(OC)C=C3)SC2=C1Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tardif M, Beauchamp D, Bergeron Y, Lessard C, Gourde P, Bergeron MG. L-651,392, a potent leukotriene inhibitor, controls inflammatory process in Escherichia coli pyelonephritis. Antimicrob Agents Chemother. 1994 Jul;38(7):1555-60. PubMed PMID: 7979288; PubMed Central PMCID: PMC284592. 2: Huber W, Trautmann M, Becker I, Schenck U, Peskar BM, Schepp W. Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. Am J Physiol. 1993 Dec;265(6 Pt 1):G1021-8. PubMed PMID: 8279553. 3: Igarashi Y, Lundgren JD, Shelhamer JH, Kaliner MA, White MV. Effects of inhibitors of arachidonic acid metabolism on serotonin release from rat basophilic leukemia cells. Immunopharmacology. 1993 Mar-Apr;25(2):131-44. PubMed PMID: 8500985. 4: Kuratomi Y, Lefferts PL, Christman BW, Parker RE, Smith WG, Mueller RA, Snapper JR. Effect of a 5-lipoxygenase inhibitor on endotoxin-induced pulmonary dysfunction in awake sheep. J Appl Physiol (1985). 1993 Feb;74(2):596-605. PubMed PMID: 8384614. 5: Leikauf GD. Mechanisms of aldehyde-induced bronchial reactivity: role of airway epithelium. Res Rep Health Eff Inst. 1992 Feb;(49):1-35. PubMed PMID: 1315139. 6: Phillips C. Induction of leukotriene production before antigen challenge enhances antibody affinity in genetically selected mice. Cell Immunol. 1991 Aug;136(1):173-84. PubMed PMID: 2060019. 7: Zhang S, Myers S, Castro GA. Inhibition of anaphylaxis-evoked intestinal fluid secretion by the dual application of an H1 antagonist and cyclooxygenase inhibitor. Gastroenterology. 1991 Apr;100(4):922-8. PubMed PMID: 1705907. 8: Cabrol D, Dallot E, Bienkiewicz A, el Alj A, Sedbon E, Cedard L. Cyclooxygenase and lipoxygenase inhibitors--induced changes in the distribution of glycosaminoglycans in the pregnant rat uterine cervix. Prostaglandins. 1990 May;39(5):515-23. PubMed PMID: 2112771. 9: Pignol B, Henane S, Chaumeron S, Mencia-Huerta JM, Braquet P. Modulation of the priming effects of platelet-activating factor on the release of interleukin-1 from lipopolysaccharide-stimulated rat spleen macrophages. J Lipid Mediat. 1990;2 Suppl:S93-9. PubMed PMID: 2133288. 10: Zhang S, Castro GA. Involvement of type I hypersensitivity in rapid rejection of Trichinella spiralis from adult rats. Int Arch Allergy Appl Immunol. 1990;93(2-3):272-9. PubMed PMID: 2099353. 11: Mattila P, Renkonen R. Gamma-interferon induces prostacyclin and prostaglandin but not lipoxygenase product synthesis in rat endothelial cells. Immunol Lett. 1989 Jul;22(1):59-63. PubMed PMID: 2506125. 12: Leikauf GD, Doupnik CA, Leming LM, Wey HE. Sulfidopeptide leukotrienes mediate acrolein-induced bronchial hyperresponsiveness. J Appl Physiol (1985). 1989 Apr;66(4):1838-45. PubMed PMID: 2543658. 13: Leszczynski D, Häyry P. Eicosanoids are regulatory molecules in gamma-interferon-induced endothelial antigenicity and adherence for leucocytes. FEBS Lett. 1989 Jan 2;242(2):383-6. PubMed PMID: 2492473. 14: Wallace JL, MacNaughton WK, Morris GP, Beck PL. Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease. Gastroenterology. 1989 Jan;96(1):29-36. PubMed PMID: 2535830. 15: Opas EE, Argenbright LW, Humes JL. An enzymatic method for distinguishing the stereoisomers of 12-hydroxyeicosatetraenoic acid in human epidermis and psoriatic scale. Br J Dermatol. 1989 Jan;120(1):49-58. PubMed PMID: 2517876. 16: Perlman MB, Johnson A, Jubiz W, Malik AB. Lipoxygenase products induce neutrophil activation and increase endothelial permeability after thrombin-induced pulmonary microembolism. Circ Res. 1989 Jan;64(1):62-73. PubMed PMID: 2491795. 17: Prescott MF, McBride CK, Venturini CM, Gerhardt SC. Leukocyte stimulation of intimal lesion formation is inhibited by treatment with diclofenac sodium and dexamethasone. J Cardiovasc Pharmacol. 1989;14 Suppl 6:S76-81. PubMed PMID: 2478829. 18: Heyd TJ, Perez RV, Trocki O, Alexander JW. Manipulations of arachidonic acid metabolism using a 5-lipoxygenase inhibitor in transfusion-induced immunosuppression. Transplant Proc. 1988 Dec;20(6):1186-9. PubMed PMID: 3144072. 19: Warner JA, Lichtenstein LM, MacGlashan DW Jr. Effects of a specific inhibitor of the 5-lipoxygenase pathway on mediator release from human basophils and mast cells. J Pharmacol Exp Ther. 1988 Oct;247(1):218-22. PubMed PMID: 3139865. 20: Jacques CA, Spur BW, Crea AE, Lee TH. The contractile activities of lipoxin A4 and lipoxin B4 for guinea-pig airway tissues. Br J Pharmacol. 1988 Oct;95(2):562-8. PubMed PMID: 2852525; PubMed Central PMCID: PMC1854178.