VU0183254 | CAS#663212-40-6 | allosteric modulator

MedKoo Cat#: 558402 | Name: VU0183254

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0183254 is an antagonist of insect olfactory receptors (ORs) acting at a binding site on the Orco subunit, capable of broadly inhibiting odor-mediated OR complex activation.

Chemical Structure

VU0183254

CAS#663212-40-6

Theoretical Analysis

MedKoo Cat#: 558402

Name: VU0183254

CAS#: 663212-40-6

Chemical Formula: C22H18N4O2S2

Exact Mass: 434.0900

Molecular Weight: 434.53

Elemental Analysis: C, 60.81; H, 4.18; N, 12.89; O, 7.36; S, 14.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VU0183254; VU-0183254; VU 0183254; VUANT 1;

IUPAC/Chemical Name

2-(4-Ethyl-5-furan-2-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-1-phenothiazin-10-yl-ethanone

InChi Key

ASZRHXKUEMHBKN-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H18N4O2S2/c1-2-25-21(17-10-7-13-28-17)23-24-22(25)29-14-20(27)26-15-8-3-5-11-18(15)30-19-12-6-4-9-16(19)26/h3-13H,2,14H2,1H3

SMILES Code

CCN1C(SCC(N2C3=C(C=CC=C3)SC4=CC=CC=C24)=O)=NN=C1C5=CC=CO5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 434.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ. Allosteric antagonism of insect odorant receptor ion channels. PLoS One. 2012;7(1):e30304. doi: 10.1371/journal.pone.0030304. Epub 2012 Jan 17. PubMed PMID: 22272331; PubMed Central PMCID: PMC3260273. 2: Chen S, Luetje CW. Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit. PLoS One. 2012;7(5):e36784. doi: 10.1371/journal.pone.0036784. Epub 2012 May 8. PubMed PMID: 22590607; PubMed Central PMCID: PMC3348135.