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MedKoo Cat#: 597792 | Name: Phelorphan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Phelorphan is an enkephalinase inhibitor.

Chemical Structure

Phelorphan
Phelorphan
CAS#110871-16-4

Theoretical Analysis

MedKoo Cat#: 597792

Name: Phelorphan

CAS#: 110871-16-4

Chemical Formula: C20H22N2O4S

Exact Mass: 386.1300

Molecular Weight: 386.46

Elemental Analysis: C, 62.16; H, 5.74; N, 7.25; O, 16.56; S, 8.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Phelorphan;
IUPAC/Chemical Name
(2-mercaptoacetyl)-L-phenylalanyl-L-phenylalanine
InChi Key
DPRJEBOTAKMRQV-IRXDYDNUSA-N
InChi Code
InChI=1S/C20H22N2O4S/c23-18(13-27)21-16(11-14-7-3-1-4-8-14)19(24)22-17(20(25)26)12-15-9-5-2-6-10-15/h1-10,16-17,27H,11-13H2,(H,21,23)(H,22,24)(H,25,26)/t16-,17-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=CC=C2)NC(CS)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 386.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Van Amsterdam JG, Llorens-Cortes C. Inhibition of enkephalin degradation by phelorphan: effects on striatal [Met5]enkephalin levels and jump latency in mouse hot plate test. Eur J Pharmacol. 1988 Sep 23;154(3):319-24. PubMed PMID: 3234484. 2: Haffmans J, Walsum MV, van Amsterdam JC, Dzoljic MR. Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats. Neuroscience. 1987 Jul;22(1):233-6. PubMed PMID: 2888045. 3: van Amsterdam JG, van Buuren KJ, Krielaart MJ, Zuiderveld OP, Tijms RP. Effect of inhibitors of enkephalin degradation in the isolated guinea-pig ileum. Life Sci. 1988;43(19):1529-36. PubMed PMID: 3193845. 4: Dzoljic MR. Enkephalinase inhibitors attenuate naloxone-precipitated withdrawal syndrome. NIDA Res Monogr. 1986;75:575-8. PubMed PMID: 3123978. 5: Van Amsterdam JG, Van Buuren KJ, Blad MW, Soudijn W. Synthesis of enkephalinase B inhibitors, and their activity on isolated enkephalin-degrading enzymes. Eur J Pharmacol. 1987 Mar 31;135(3):411-8. PubMed PMID: 3556201.