Isoalantolactone | CAS#470-17-7 | anti-apoptotic

MedKoo Cat#: 592156 | Name: Isoalantolactone

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.

Chemical Structure

Isoalantolactone

CAS#470-17-7

Theoretical Analysis

MedKoo Cat#: 592156

Name: Isoalantolactone

CAS#: 470-17-7

Chemical Formula: C15H20O2

Exact Mass: 232.1463

Molecular Weight: 242.32

Elemental Analysis: C, 77.55; H, 8.68; O, 13.77

Price and Availability

Size	Price	Availability
10mg	USD 250.00	2 Weeks
50mg	USD 500.00	2 Weeks
100mg	USD 750.00	2 Weeks

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Related CAS #

No Data

Synonym

Isoalantolactone; NSC 601353; NSC-601353; NSC601353

IUPAC/Chemical Name

Eudesma-4(14),11(13)-dien-12-oic acid, 8-beta-hydroxy-, gamma-lactone

InChi Key

CVUANYCQTOGILD-QVHKTLOISA-N

InChi Code

InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h11-13H,1-2,4-8H2,3H3/t11-,12+,13-,15-/m1/s1

SMILES Code

O=C(O[C@@](C[C@@]1(C)CCC2)([H])[C@]3([H])C[C@@]1([H])C2=C)C3=C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 242.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Alantolactone and Isoalantolactone Prevent Amyloid β(25-35) -induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice. Phytother Res. 2017 May;31(5):801-811. doi: 10.1002/ptr.5804. Epub 2017 Mar 21. PubMed PMID: 28326625. 13: Mohan S, Gupta D. Phytochemical analysis and differential in vitro cytotoxicity assessment of root extracts of Inula racemosa. Biomed Pharmacother. 2017 May;89:781-795. doi: 10.1016/j.biopha.2017.02.053. Epub 2017 Mar 6. PubMed PMID: 28273640. 14: Guan YH, Zhang XD, Cai H, Yang CH. [Isoalantolactone Inhibits Proliferation of K562/A02 Cells through Caspase-Dependent Apoptotic Pathway]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Feb;25(1):110-114. doi: 10.7534/j.issn.1009-2137.2017.01.019. Chinese. PubMed PMID: 28245385. 15: Gao S, Wang Q, Tian XH, Li HL, Shen YH, Xu XK, Wu GZ, Hu ZL, Zhang WD. Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis. 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