NSC-689857 | CAS#241127-79-7 | Skp2-Cks1 inhibitor

MedKoo Cat#: 563269 | Name: NSC-689857

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-689857 is an inhibitor of the Skp2-Cks1 protein-protein interaction and p27Kip1 ubiquitination in vitro.

Chemical Structure

NSC-689857

CAS#241127-79-7

Theoretical Analysis

MedKoo Cat#: 563269

Name: NSC-689857

CAS#: 241127-79-7

Chemical Formula: C25H29NO4

Exact Mass: 407.2097

Molecular Weight: 407.51

Elemental Analysis: C, 73.69; H, 7.17; N, 3.44; O, 15.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NSC-689857; NSC 689857; NSC689857;

IUPAC/Chemical Name

1-Adamantylmethyl 4-((2,5-dihydroxybenzyl)amino)benzoate

InChi Key

MXKHJVTZHIIIMQ-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H29NO4/c27-22-5-6-23(28)20(10-22)14-26-21-3-1-19(2-4-21)24(29)30-15-25-11-16-7-17(12-25)9-18(8-16)13-25/h1-6,10,16-18,26-28H,7-9,11-15H2

SMILES Code

O=C(OCC12CC3CC(C2)CC(C3)C1)C4=CC=C(NCC5=CC(O)=CC=C5O)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 407.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ungermannova D, Lee J, Zhang G, Dallmann HG, McHenry CS, Liu X. High-throughput screening AlphaScreen assay for identification of small-molecule inhibitors of ubiquitin E3 ligase SCFSkp2-Cks1. J Biomol Screen. 2013 Sep;18(8):910-20. doi: 10.1177/1087057113485789. Epub 2013 Apr 15. PubMed PMID: 23589337; PubMed Central PMCID: PMC4168015.