IUPAC/Chemical Name
((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-valyl-L-phenylalanine
InChi Key
GGMURINELPSPEF-ANULTFPQSA-N
InChi Code
InChI=1S/C24H31N3O5/c1-15(2)20(22(29)26-19(24(31)32)14-17-11-7-4-8-12-17)27-23(30)21(28)18(25)13-16-9-5-3-6-10-16/h3-12,15,18-21,28H,13-14,25H2,1-2H3,(H,26,29)(H,27,30)(H,31,32)/t18-,19+,20+,21+/m1/s1
SMILES Code
CC([C@H](NC([C@@H](O)[C@H](N)Cc1ccccc1)=O)C(N[C@H](C(O)=O)Cc2ccccc2)=O)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
441.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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1: Bank U, Tadje J, Täger M, Wolke C, Bukowska A, Ittenson A, Reinhold D, Helmuth M, Ansorge S, Shakespeare A, Vieth M, Malfertheiner P, Naumann M, Lendeckel U. Inhibition of alanyl-aminopeptidase on CD4+CD25+ regulatory T-cells enhances expression of FoxP3 and TGF-beta1 and ameliorates acute colitis in mice. Int J Mol Med. 2007 Oct;20(4):483-92. PubMed PMID: 17786278.
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3: Bukowska A, Tadje J, Arndt M, Wolke C, Kähne T, Bartsch J, Faust J, Neubert K, Hashimoto Y, Lendeckel U. Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets. Biol Chem. 2003 Apr;384(4):657-65. PubMed PMID: 12751795.
4: Noguchi Y, Nagata H, Koganei H, Kodera Y, Hiroto M, Nishimura H, Inada Y, Matsushima A. Isolation and characterization of aminopeptidase (Jc-peptidase) from Japanese cedar pollen (Cryptomeria japonica). J Agric Food Chem. 2002 Jun 5;50(12):3540-3. PubMed PMID: 12033825.
