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MedKoo Cat#: 597763 | Name: GS-9191

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GS-9191 is a novel antipapillomavirus agent.

Chemical Structure

GS-9191
GS-9191
CAS#859209-84-0

Theoretical Analysis

MedKoo Cat#: 597763

Name: GS-9191

CAS#: 859209-84-0

Chemical Formula: C37H51N8O5P

Exact Mass: 718.3720

Molecular Weight: 718.83

Elemental Analysis: C, 61.82; H, 7.15; N, 15.59; O, 11.13; P, 4.31

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GS-9191; GS 9191; GS9191;
IUPAC/Chemical Name
diisobutyl 2,2'-((((2-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)ethoxy)methyl)phosphanediyl)bis(azanediyl))(2S,2'S)-bis(3-phenylpropanoate)
InChi Key
WGBBLRPRKPODRO-CONSDPRKSA-N
InChi Code
InChI=1S/C37H51N8O5P/c1-25(2)21-49-35(46)30(19-27-11-7-5-8-12-27)43-51(44-31(36(47)50-22-26(3)4)20-28-13-9-6-10-14-28)24-48-18-17-45-23-39-32-33(40-29-15-16-29)41-37(38)42-34(32)45/h5-14,23,25-26,29-31,43-44H,15-22,24H2,1-4H3,(H3,38,40,41,42)/t30-,31-/m0/s1
SMILES Code
NC1=NC(NC2CC2)=C3N=CN(CCOCP(N[C@@H](CC4=CC=CC=C4)C(OCC(C)C)=O)N[C@@H](CC5=CC=CC=C5)C(OCC(C)C)=O)C3=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 718.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191. Antimicrob Agents Chemother. 2011 May;55(5):2166-73. doi: 10.1128/AAC.01603-10. Epub 2011 Mar 7. PubMed PMID: 21383096; PubMed Central PMCID: PMC3088193. 2: Wolfgang GH, Shibata R, Wang J, Ray AS, Wu S, Doerrfler E, Reiser H, Lee WA, Birkus G, Christensen ND, Andrei G, Snoeck R. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions. Antimicrob Agents Chemother. 2009 Jul;53(7):2777-84. doi: 10.1128/AAC.00103-09. Epub 2009 Apr 27. PubMed PMID: 19398642; PubMed Central PMCID: PMC2704673. 3: De Clercq E. Dancing with chemical formulae of antivirals: a personal account. Biochem Pharmacol. 2013 Sep 15;86(6):711-25. doi: 10.1016/j.bcp.2013.07.012. Epub 2013 Jul 19. Review. PubMed PMID: 23876344. 4: Rai MA, Pannek S, Fichtenbaum CJ. Emerging reverse transcriptase inhibitors for HIV-1 infection. Expert Opin Emerg Drugs. 2018 Jun;23(2):149-157. doi: 10.1080/14728214.2018.1474202. Epub 2018 May 10. PubMed PMID: 29737220.