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MedKoo Cat#: 597758 | Name: alpha-Gliadin (43-49)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

alpha-Gliadin (43-49) is a Gliadian sequence peptide which induced leukocyte migration inhibition, but could be blocked by naloxone.

Chemical Structure

alpha-Gliadin (43-49)
alpha-Gliadin (43-49)
CAS#107936-65-2

Theoretical Analysis

MedKoo Cat#: 597758

Name: alpha-Gliadin (43-49)

CAS#: 107936-65-2

Chemical Formula: C43H57N9O11

Exact Mass: 875.4178

Molecular Weight: 875.98

Elemental Analysis: C, 58.96; H, 6.56; N, 14.39; O, 20.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
alpha-Gliadin (43-49); Tyr-pro-gln-pro-gln-pro-phe;
IUPAC/Chemical Name
L-tyrosyl-L-prolyl-L-glutaminyl-L-prolyl-L-glutaminyl-L-prolyl-L-phenylalanine
InChi Key
QGFISQMZJLWFEE-NXBWRCJVSA-N
InChi Code
InChI=1S/C43H57N9O11/c44-28(23-26-12-14-27(53)15-13-26)40(59)50-20-4-9-32(50)37(56)47-29(16-18-35(45)54)41(60)51-21-5-10-33(51)38(57)48-30(17-19-36(46)55)42(61)52-22-6-11-34(52)39(58)49-31(43(62)63)24-25-7-2-1-3-8-25/h1-3,7-8,12-15,28-34,53H,4-6,9-11,16-24,44H2,(H2,45,54)(H2,46,55)(H,47,56)(H,48,57)(H,49,58)(H,62,63)/t28-,29-,30-,31-,32-,33-,34-/m0/s1
SMILES Code
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@H](CCC(N)=O)NC([C@H]3N(C([C@H](CCC(N)=O)NC([C@H]4N(C([C@H](CC5=CC=C(O)C=C5)N)=O)CCC4)=O)=O)CCC3)=O)=O)CCC2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 875.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Payan DG, Horváth K, Gráf L. Specific high-affinity binding sites for a synthetic gliadin heptapeptide on human peripheral blood lymphocytes. Life Sci. 1987 Mar 23;40(12):1229-36. PubMed PMID: 3561149. 2: Skoczowski A, Obtułowicz K, Czarnobilska E, Dyga W, Stachowicz M, Waga J. Patient-dependent differentiation of gluten protein IgE-binding epitopes in wheat allergy. Przegl Lek. 2013;70(12):1043-7. PubMed PMID: 24720124. 3: Gráf L, Horváth K, Berzétei I, Antoni F. [Gliadin and gliadophins: studies of structure and mechanism of action in lymphocytes in children with celiac disease]. Orv Hetil. 1986 Dec 21;127(51):3105-10. Hungarian. PubMed PMID: 3822445.