|
Solvent |
mg/mL |
mM |
comments |
Solubility |
DMF |
25.0 |
64.11 |
|
DMSO |
35.0 |
89.75 |
|
Ethanol |
20.0 |
51.29 |
|
PBS (pH 7.2) |
0.1 |
0.36 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
389.96
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Grinchii D, Paliokha R, Tseilikman V, Dremencov E. Inhibition of cytochrome P450 by proadifen diminishes the excitability of brain serotonin neurons in rats. Gen Physiol Biophys. 2018 Sep;37(6):711-713. doi: 10.4149/gpb_2018040. Epub 2018 Nov 15. PMID: 30431437.
2: Liu DX, Zhao MM. [Determination of Methcathinone in Urine by GC-MS]. Fa Yi Xue Za Zhi. 2017 Oct;33(5):506-508. Chinese. doi: 10.3969/j.issn.1004-5619.2017.05.012. Epub 2017 Oct 25. PMID: 29275556.
3: Sykes BG, Van Steyn PM, Vignali JD, Winalski J, Lozier J, Bell WE, Turner JE. The Relationship between Estrogen and Nitric Oxide in the Prevention of Cardiac and Vascular Anomalies in the Developing Zebrafish (Danio Rerio). Brain Sci. 2016 Oct 26;6(4):51. doi: 10.3390/brainsci6040051. PMID: 27792175; PMCID: PMC5187565.
4: Hu G, Li X, Zhang S, Wang X. Association of rat thoracic aorta dilatation by astragaloside IV with the generation of endothelium-derived hyperpolarizing factors and nitric oxide, and the blockade of Ca2+ channels. Biomed Rep. 2016 Jul;5(1):27-34. doi: 10.3892/br.2016.680. Epub 2016 May 18. PMID: 27347401; PMCID: PMC4907089.
5: Huang YC, Han YS. Determining anti-betanodavirus compounds through a GF-1 cell-based screening platform. Antiviral Res. 2014 May;105:47-53. doi: 10.1016/j.antiviral.2014.02.018. Epub 2014 Feb 28. PMID: 24583156.
6: Smith GB, Bend JR, Bedard LL, Reid KR, Petsikas D, Massey TE. Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in peripheral human lung microsomes. Drug Metab Dispos. 2003 Sep;31(9):1134-41. doi: 10.1124/dmd.31.9.1134. PMID: 12920169.
7: Kitamura S, Shimizu Y, Shiraga Y, Yoshida M, Sugihara K, Ohta S. Reductive metabolism of p,p'-DDT and o,p'-DDT by rat liver cytochrome P450. Drug Metab Dispos. 2002 Feb;30(2):113-8. doi: 10.1124/dmd.30.2.113. PMID: 11792678.
8: Jin ZY, Gu MS, Luo Y. [Quantitative analysis of soporific sedative drugs and local anesthetic drugs with unidentical standard substance by GC-AED]. Yao Xue Xue Bao. 1997 Nov;32(11):865-8. Chinese. PMID: 11596207.
9: Szotáková B, Wsól V, Skálová L, Kvasnicková E. Role of cytochrome P4501A in biotransformation of the potential anticancer drug oracin. Exp Toxicol Pathol. 1999 Jul;51(4-5):428-31. doi: 10.1016/S0940-2993(99)80034-7. PMID: 10445410.
10: Eissa FZ, Qualls CW Jr, Burrows GE, Lish JW. Effects of feeding Artemisia filifolia and Helenium flexuosum on rabbit cytochrome P450 isozymes. Vet Hum Toxicol. 1996 Feb;38(1):19-23. PMID: 8825743.
11: Robertson IG, Bland TJ. Inhibition by SKF-525A of the aldehyde oxidase- mediated metabolism of the experimental antitumour agent acridine carboxamide. Biochem Pharmacol. 1993 May 25;45(10):2159-62. doi: 10.1016/0006-2952(93)90031-q. PMID: 8512597.
12: Engberg G, Elebring T, Nissbrandt H. Deprenyl (selegiline), a selective MAO-B inhibitor with active metabolites; effects on locomotor activity, dopaminergic neurotransmission and firing rate of nigral dopamine neurons. J Pharmacol Exp Ther. 1991 Nov;259(2):841-7. PMID: 1658311.
13: Ross SB. Further studies on the high-affinity binding of 3H-alaproclate to membranes from rat liver and some other tissues. Pharmacol Toxicol. 1990 Mar;66(3):170-5. doi: 10.1111/j.1600-0773.1990.tb00727.x. PMID: 2333272.
14: Morris DD, Moore JN, Wiltshire N, Fischer K. Proadifen-induced production of prostacyclin by equine peritoneal macrophages. Am J Vet Res. 1989 May;50(5):747-50. PMID: 2499232.
15: Rossi M, Markovitz S, Callahan T. Defining the active site of cytochrome P-450: the crystal and molecular structure of an inhibitor, SKF-525A. Carcinogenesis. 1987 Jul;8(7):881-7. doi: 10.1093/carcin/8.7.881. PMID: 3594722.
16: Taylor RW, Greutink C, Jain NC. Identification of underivatized basic drugs in urine by capillary column gas chromatography. J Anal Toxicol. 1986 Sep- Oct;10(5):205-8. doi: 10.1093/jat/10.5.205. PMID: 3773481.
17: Green J, Large PJ. Subcellular localization and properties of partially purified dimethylamine and trimethylamine mono-oxygenase activities in Candida utilis. J Gen Microbiol. 1984 Oct;130(10):2577-88. doi: 10.1099/00221287-130-10-2577. PMID: 6542583.
18: Green J, Large PJ. Oxidation of dimethylamine and trimethylamine in methazotrophic yeasts by microsomal mono-oxygenases sensitive to carbon monoxide. Biochem Biophys Res Commun. 1983 Jun 29;113(3):900-7. doi: 10.1016/0006-291x(83)91084-7. PMID: 6870901.
19: Brookman S, Kourounakis P. Effect of pregnenolone-16 alpha-carbonitrile on the biliary and urinary excretion of imipramine and some of its metabolites in rats. Arzneimittelforschung. 1982;32(10):1298-301. PMID: 6891231.
20: Sylvester JT, McGowan C. The effects of agents that bind to cytochrome P-450 on hypoxic pulmonary vasoconstriction. Circ Res. 1978 Sep;43(3):429-37. doi: 10.1161/01.res.43.3.429. PMID: 679425.