Synonym
Antibiotic K 4; I5B1; I5-B1; I5 B1; K-4; K4; K 4;
IUPAC/Chemical Name
((R)-1-((S)-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-3-methyl-2-(methylamino)butanamido)-2-(4-hydroxyphenyl)ethyl)phosphonic acid
InChi Key
MWACDKDUEPIRCE-HBMCJLEFSA-N
InChi Code
InChI=1S/C23H32N3O6P/c1-15(2)21(25-3)23(29)26(19(22(24)28)13-16-7-5-4-6-8-16)20(33(30,31)32)14-17-9-11-18(27)12-10-17/h4-12,15,19-21,25,27H,13-14H2,1-3H3,(H2,24,28)(H2,30,31,32)/t19-,20+,21-/m0/s1
SMILES Code
O=C(N)[C@H](CC1=CC=CC=C1)N(C([C@H](C(C)C)NC)=O)[C@H](P(O)(O)=O)CC2=CC=C(O)C=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
477.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Koguchi T, Yamada K, Yamato M, Okachi R, Nakayama K, Kase H. K-4, a novel inhibitor of angiotensin I converting enzyme produced by Actinomadura spiculosospora. J Antibiot (Tokyo). 1986 Mar;39(3):364-71. PubMed PMID: 3009378.
2: VONBERG G. [Experience with Imprex K 4]. Zahnarztl Welt Zahnarztl Reform Zwr. 1950 Aug 10;5(15):439-40. Undetermined Language. PubMed PMID: 14782536.
3: VOLLRATH W. [Imprex K 4 homogenized, the impression of choice in practice and laboratory]. Zahnarztl Rundsch. 1951 Nov;60(21-22):428-32. Undetermined Language. PubMed PMID: 14931913.
4: PETROV VA, PALLADIEVA NM, PIVANOVA PS. [Dosimetric and qualitative characteristics of the primary and diffuse roentgen irradiation of diagnostic apparatus URDd-110-K-4]. Vestn Rentgenol Radiol. 1962 Mar-Apr;37:42-7. Russian. PubMed PMID: 14485929.
5: ALEKSEEV BA. [Aiming apparatus for x-ray machine URD-d 110 K-4 (universal divisor)]. Vestn Rentgenol Radiol. 1958 May-Jun;33(3):63-4. Russian. PubMed PMID: 13581462.
6: GOLIADZE AS. [Description of a tomographic apparatus for x-ray machine URD-d 110 K-4 M-1, 1954 model]. Vestn Rentgenol Radiol. 1958 May-Jun;33(3):61-3. Russian. PubMed PMID: 13581461.
7: Kido Y, Hamakado T, Anno M, Miyagawa E, Motoki Y, Wakamiya T, Shiba T. Isolation and characterization of I5B2, a new phosphorus containing inhibitor of angiotensin I converting enzyme produced by Actinomadura sp. J Antibiot (Tokyo). 1984 Sep;37(9):965-9. PubMed PMID: 6094415.
