Synonym
Amogastrin; AOC-tetragastrin; Amogastrina;
IUPAC/Chemical Name
(7S,10S,13S)-7-((1H-indol-3-yl)methyl)-3,3-dimethyl-10-(2-(methylthio)ethyl)-5,8,11-trioxo-13-(((S)-1-oxo-1-(phenylamino)propan-2-yl)carbamoyl)-4-oxa-6,9,12-triazapentadecan-15-oic acid
InChi Key
JQFKOXLANWUNTQ-FYYOVZQQSA-N
InChi Code
InChI=1S/C35H46N6O8S/c1-6-35(3,4)49-34(48)41-27(18-22-20-36-25-15-11-10-14-24(22)25)33(47)39-26(16-17-50-5)31(45)40-28(19-29(42)43)32(46)37-21(2)30(44)38-23-12-8-7-9-13-23/h7-15,20-21,26-28,36H,6,16-19H2,1-5H3,(H,37,46)(H,38,44)(H,39,47)(H,40,45)(H,41,48)(H,42,43)/t21-,26-,27-,28-/m0/s1
SMILES Code
C[C@@H](C(NC1=CC=CC=C1)=O)NC([C@H](CC(O)=O)NC([C@H](CCSC)NC([C@H](CC2=CNC3=C2C=CC=C3)NC(OC(C)(C)CC)=O)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
710.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Saitoh O, Tei H, Okumura Y, Asada S, Hirata I, Ohshiba S. Effect of amogastrin on the release of various prostaglandins into gastric lumen in man. Jpn J Med. 1989 Mar-Apr;28(2):175-9. PubMed PMID: 2733241.
2: Okuyama S, Mishina H. Amogastrin for the 99mTc-pertechnetate imaging of the gastric mucosa. Radioisotopes. 1982 Mar;31(3):141-4. PubMed PMID: 6285422.
3: Kohli Y, Katoh T, Suzuki K. Antisecretory effect of a PGE2 derivative, enprostil (TA/RS-84135): inhibitory action of amogastrin-stimulated secretion. Drugs Exp Clin Res. 1988;14(11):673-8. PubMed PMID: 3149933.
4: Okuyama S, Mishina H, Yamagata R, Yamamoto K, Nagashima H, Taima T. A case of early gastric cancer whose diagnosis was expedited by amogastrin-99mTc pertechnetate scintigraphy. Tohoku J Exp Med. 1982 Jun;137(2):231-2. PubMed PMID: 6287668.
5: Isobe Y, Hirose-Kijima H, Muramatsu M, Aihara H. Gastric protective effects of gastric secretagogues on 0.6N HCl-induced gastric lesions in rats. Arch Int Pharmacodyn Ther. 1988 Sep-Oct;295:270-81. PubMed PMID: 3245741.
