Snf 9007 | CAS#156161-88-5 | Cholecystokinin antagonist

MedKoo Cat#: 597726 | Name: Snf 9007

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Snf 9007 is a cholecystokinin antagonist.

Chemical Structure

Snf 9007

CAS#156161-88-5

Theoretical Analysis

MedKoo Cat#: 597726

Name: Snf 9007

CAS#: 156161-88-5

Chemical Formula: C55H66N10O13

Exact Mass: 1074.4811

Molecular Weight: 1075.19

Elemental Analysis: C, 61.44; H, 6.19; N, 13.03; O, 19.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Snf 9007; Snf-9007; Snf9007; Asp-tyr-D-phe-gly-trp-(N-Me)nle-asp-phe-NH2;

IUPAC/Chemical Name

(3S,6S,9S,15R,18S,21S)-21-amino-3-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-benzyl-6-butyl-18-(4-hydroxybenzyl)-9-((1-methyl-1H-indol-3-yl)methyl)-5,8,11,14,17,20-hexaoxo-4,7,10,13,16,19-hexaazatricosanedioic acid

InChi Key

MEBJVRFUJPOFQA-GLEMDPEOSA-N

InChi Code

InChI=1S/C55H66N10O13/c1-3-4-18-39(52(75)64-44(29-48(70)71)55(78)61-40(49(57)72)24-32-13-7-5-8-14-32)60-54(77)43(27-35-31-65(2)45-19-12-11-17-37(35)45)59-46(67)30-58-51(74)41(25-33-15-9-6-10-16-33)63-53(76)42(26-34-20-22-36(66)23-21-34)62-50(73)38(56)28-47(68)69/h5-17,19-23,31,38-44,66H,3-4,18,24-30,56H2,1-2H3,(H2,57,72)(H,58,74)(H,59,67)(H,60,77)(H,61,78)(H,62,73)(H,63,76)(H,64,75)(H,68,69)(H,70,71)/t38-,39-,40-,41+,42-,43-,44-/m0/s1

SMILES Code

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CC(O)=O)NC([C@H](CCCC)NC([C@H](CC2=CN(C)C3=C2C=CC=C3)NC(CNC([C@@H](CC4=CC=CC=C4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,075.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Roerig SC, Williams CL, Hruby VJ, Burks TF, Rosenfeld GC. Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells. Regul Pept. 1996 Jan 16;61(1):51-6. PubMed PMID: 8701027. 2: Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ. The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. J Med Chem. 1996 Sep 27;39(20):4120-4. PubMed PMID: 8831778. 3: Rao RK, Levenson S, Fang SN, Hruby VJ, Yamamura HI, Porreca F. Characterization of SNF 9007, a novel cholecystokinin/opoid ligand in mouse ileum in vitro: evidence for involvement of cholecystokininA and cholecystokininB receptors in regulation of ion transport. J Pharmacol Exp Ther. 1994 Feb;268(2):1003-9. PubMed PMID: 8113956. 4: Rao RK, Levenson S, Fang SN, Hruby VJ, Yamamura HI, Porreca F. Role of substance P in the regulation of ion transport by CCKA and CCKB receptors in mouse ileum. Ann N Y Acad Sci. 1994 Mar 23;713:420-1. PubMed PMID: 7514373. 5: Williams CL, Rosenfeld GC, Dafny N, Fang SN, Hruby VJ, Bowden G, Cullinan CA, Burks TF. SNF9007: a novel analgesic that acts simultaneously at delta 1, delta 2 and mu opioid receptors. J Pharmacol Exp Ther. 1994 May;269(2):750-5. PubMed PMID: 8182541.