Neuropeptide DF2 | CAS#149471-11-4 | neuropeptide

MedKoo Cat#: 597724 | Name: Neuropeptide DF2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neuropeptide DF2 is an FMRFamide-related neuropeptide from crayfish, Procambarus clarkii.

Chemical Structure

Neuropeptide DF2

CAS#149471-11-4

Theoretical Analysis

MedKoo Cat#: 597724

Name: Neuropeptide DF2

CAS#: 149471-11-4

Chemical Formula: C44H67N15O10

Exact Mass: 965.5195

Molecular Weight: 966.11

Elemental Analysis: C, 54.70; H, 6.99; N, 21.75; O, 16.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Neuropeptide DF2; DF(2) Neuropeptide; Drnflrfamide;

IUPAC/Chemical Name

(6S,9S,12S,15S,18S,21S)-1,21-diamino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-(2-amino-2-oxoethyl)-12-benzyl-18-(3-guanidinopropyl)-1-imino-9-isobutyl-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatricosan-23-oic acid

InChi Key

DWSQPUHNGRSXSJ-MRNVWEPHSA-N

InChi Code

InChI=1S/C44H67N15O10/c1-24(2)19-31(40(67)55-29(16-10-18-53-44(50)51)38(65)56-30(36(47)63)20-25-11-5-3-6-12-25)57-41(68)32(21-26-13-7-4-8-14-26)58-42(69)33(23-34(46)60)59-39(66)28(15-9-17-52-43(48)49)54-37(64)27(45)22-35(61)62/h3-8,11-14,24,27-33H,9-10,15-23,45H2,1-2H3,(H2,46,60)(H2,47,63)(H,54,64)(H,55,67)(H,56,65)(H,57,68)(H,58,69)(H,59,66)(H,61,62)(H4,48,49,52)(H4,50,51,53)/t27-,28-,29-,30-,31-,32-,33-/m0/s1

SMILES Code

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 966.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Weiss T, Kreissl S, Rathmayer W. Localization of a FMRFamide-related peptide in efferent neurons and analysis of neuromuscular effects of DRNFLRFamide (DF2) in the crustacean Idotea emarginata. Eur J Neurosci. 2003 Jan;17(2):239-48. PubMed PMID: 12542660. 2: Friedrich RW, Quigley PA, Srivastava M, Skerrett M, Mercier AJ. Temperature dependence of synaptic modulation by a FMRFamide-related neuropeptide in crayfish. Neurosci Lett. 1994 Mar 14;169(1-2):56-8. PubMed PMID: 7914017. 3: Noronha KF, Mercier AJ. A role for calcium/calmodulin-dependent protein kinase in mediating synaptic modulation by a neuropeptide. Brain Res. 1995 Feb 27;673(1):70-4. PubMed PMID: 7757481. 4: Dunn TW, Mercier AJ. Synaptic modulation by a neuropeptide depends on temperature and extracellular calcium. J Neurophysiol. 2003 Apr;89(4):1807-14. PubMed PMID: 12686567. 5: Friedrich RW, Molnar GF, Schiebe M, Mercier AJ. Protein kinase C is required for long-lasting synaptic enhancement by the neuropeptide DRNFLRFamide in crayfish. J Neurophysiol. 1998 Feb;79(2):1127-31. PubMed PMID: 9463471. 6: Mercier AJ, Orchard I, TeBrugge V, Skerrett M. Isolation of two FMRFamide-related peptides from crayfish pericardial organs. Peptides. 1993 Mar-Apr;14(2):137-43. PubMed PMID: 8387183. 7: Mercier AJ, Lee J. Differential effects of neuropeptides on circular and longitudinal muscles of the crayfish hindgut. Peptides. 2002 Oct;23(10):1751-57. PubMed PMID: 12383862. 8: Rathmayer W, Djokaj S, Gaydukov A, Kreissl S. The neuromuscular junctions of the slow and the fast excitatory axon in the closer of the crab Eriphia spinifrons are endowed with different Ca2+ channel types and allow neuron-specific modulation of transmitter release by two neuropeptides. J Neurosci. 2002 Feb 1;22(3):708-17. PubMed PMID: 11826100.