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MedKoo Cat#: 558390 | Name: Caroxazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Caroxazone is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) and antidepressant drug.

Chemical Structure

Caroxazone
Caroxazone
CAS#18464-39-6

Theoretical Analysis

MedKoo Cat#: 558390

Name: Caroxazone

CAS#: 18464-39-6

Chemical Formula: C10H10N2O3

Exact Mass: 206.0700

Molecular Weight: 206.20

Elemental Analysis: C, 58.25; H, 4.89; N, 13.59; O, 23.28

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Synonym
Caroxazone;
IUPAC/Chemical Name
2-(2-Oxo-4H-1,3-benzoxazin-3-yl)acetamide
InChi Key
KYCBWEZLKCTALM-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H10N2O3/c11-9(13)6-12-5-7-3-1-2-4-8(7)15-10(12)14/h1-4H,5-6H2,(H2,11,13)
SMILES Code
O=C(N)CN1C(OC2=CC=CC=C2C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 206.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Moretti A, Caccia C, Martini A, Bonollo L, Amico A, Sega R, Nicolella V, Nicolis FB. Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers. Br J Clin Pharmacol. 1981 May;11(5):511-5. PubMed PMID: 7272163; PubMed Central PMCID: PMC1401585. 2: Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A. Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man. Br J Clin Pharmacol. 1981 Jun;11(6):611-5. PubMed PMID: 7272178; PubMed Central PMCID: PMC1402186. 3: Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E. Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man. Br J Clin Pharmacol. 1981 Jun;11(6):605-10. PubMed PMID: 7272177; PubMed Central PMCID: PMC1402193. 4: Tannhauser SL, Elsner J, Tannhauser M, Barros HM, Tannhauser MA. Effects of phenylethylamine on rat locomotor behavior and avoidance learning. Braz J Med Biol Res. 1989;22(2):213-24. PubMed PMID: 2790290. 5: Cassano GB, Conti L, Dell'Osso L, Massimetti G. Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials. Adv Biochem Psychopharmacol. 1982;32:125-39. Review. PubMed PMID: 7046361. 6: Andreeva NI. [Comparative pharmacological study of the antidepressants pyrazidol, inkazan, caroxazone and imipramine]. Farmakol Toksikol. 1982 Jul-Aug;45(4):9-13. Russian. PubMed PMID: 6889985. 7: Moretti A, Caccia C, Calderini G, Menozzi M, Amico A. Studies on the mechanism of action of caroxazone, a new antidepressant drug. Biochem Pharmacol. 1981 Oct 1;30(19):2728-31. PubMed PMID: 6170295. 8: Bernardi L, Coda S, Nicolella V, Vicario GP, Gioia B, Minghetti A, Vigevani A, Arcamone F. Radioisotopic and synthetic studies related to caroxazone metabolism in man. Arzneimittelforschung. 1979;29(9):1412-6. PubMed PMID: 583252. 9: Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A. A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline. J Int Med Res. 1978;6(5):388-94. PubMed PMID: 359383. 10: Moro L, Neri G, Rigamonti S, Carluccio A. Influence of test apparatus on the assessment of dissolution rates of caroxazone capsules. Farmaco Prat. 1981 Feb;36(2):99-106. PubMed PMID: 7215532. 11: Moretti A, Pegrassi L, Glässer AH, Suchowsky GK. [Effect of a new antidepressive drug caroxazone on cerebral monoamines]. Boll Chim Farm. 1974 Jan;113(1):36. Italian. PubMed PMID: 4846601. 12: Golovina SM, Andreeva NI. [Effect of antidepressants on the convulsive action of thiosemicarbazide, strychnine and corasol]. Biull Eksp Biol Med. 1986 Sep;102(9):290-2. Russian. PubMed PMID: 3756328. 13: Faraj BA, Carrano RA, Ali FM, Malveaux EJ, Stacciarini WM. Studies on the effect of antidepressants on kinetics and metabolism of tyramine. J Pharmacol Exp Ther. 1981 Sep;218(3):750-7. PubMed PMID: 7264958. 14: Ponzio F, Achilli G, Algeri S. A rapid and simple method for the determination of picogram levels of 3-methoxytyramine in brain tissue using liquid chromatography with electrochemical detection. J Neurochem. 1981 Apr;36(4):1361-7. PubMed PMID: 7264632. 15: Da Prada M, Kettler R, Keller HH, Haefely WE. Neurochemical effects in vitro and in vivo of the antidepressant Ro 11-1163, a specific and short-acting MAO-A inhibitor. Mod Probl Pharmacopsychiatry. 1983;19:231-45. PubMed PMID: 6865966.