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MedKoo Cat#: 597653 | Name: SK&F 39728-A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SK&F 39728-A is a bioactive chemical.

Chemical Structure

SK&F 39728-A
SK&F 39728-A
CAS#3549-17-5

Theoretical Analysis

MedKoo Cat#: 597653

Name: SK&F 39728-A

CAS#: 3549-17-5

Chemical Formula: C17H18F3NO

Exact Mass: 309.1340

Molecular Weight: 309.33

Elemental Analysis: C, 66.01; H, 5.87; F, 18.43; N, 4.53; O, 5.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
SK&F 39728-A; SK&F 1-39728; SK&F-39728-A; SK&F39728-A; Skf 39728-A;
IUPAC/Chemical Name
N-benzyl-2-methoxy-2-(3-(trifluoromethyl)phenyl)ethan-1-amine
InChi Key
AVOUWNCXBIGLOP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18F3NO/c1-22-16(12-21-11-13-6-3-2-4-7-13)14-8-5-9-15(10-14)17(18,19)20/h2-10,16,21H,11-12H2,1H3
SMILES Code
FC(C1=CC(C(OC)CNCC2=CC=CC=C2)=CC=C1)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 309.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells. Biochim Biophys Acta. 2011 Dec;1813(12):2157-64. doi: 10.1016/j.bbamcr.2011.06.021. Epub 2011 Jul 13. PubMed PMID: 21767581. 5: Swinyard EA, White HS, Wolf HH, Bondinell WE. Anticonvulsant profiles of the potent and orally active GABA uptake inhibitors SK&F 89976-A and SK&F 100330-A and four prototype antiepileptic drugs in mice and rats. Epilepsia. 1991 Jul-Aug;32(4):569-77. PubMed PMID: 1831122. 6: Blumberg AL, Wilson JW, Hieble JP. Neuroinhibitory effects of SK&F 85174, a novel dopamine receptor agonist. J Cardiovasc Pharmacol. 1985 Jul-Aug;7(4):723-32. PubMed PMID: 2410714. 7: Laurens E, Yeoh SD, Rigopoulos A, O'Keefe GJ, Tochon-Danguy HJ, Chong LW, White JM, Scott AM, Ackermann U. Fluorine-18 radiolabeling of a nitrophenyl sulfoxide and its evaluation in an SK-RC-52 model of tumor hypoxia. J Labelled Comp Radiopharm. 2016 Aug;59(10):416-23. doi: 10.1002/jlcr.3426. Epub 2016 Jul 19. PubMed PMID: 27435268. 8: Yu H, Hsu WH. SK&F 105494, a V2-vasopressin receptor antagonist, blocks oxytocin receptors in porcine myometrium. Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):365-8. PubMed PMID: 9812726. 9: Chakrin LW, Krell RD. Pharmacologic characterization of the antiallergic activity of SK&F 78729-A. J Pharmacol Exp Ther. 1978 Dec;207(3):756-66. PubMed PMID: 83359. 10: Eden RJ, Wallduck MS, Patel B, Owen DA. Autonomic and haemodynamic responses to SK & F 101468 (ropinirole), a DA2 agonist, in anaesthetised cats. Eur J Pharmacol. 1990 Jan 17;175(3):333-40. PubMed PMID: 1969802. 11: Brooks DP, Koster PF, Albrightson-Winslow CR, Stassen FL, Huffman WF, Kinter LB. SK&F 105494 is a potent antidiuretic hormone antagonist in the rhesus monkey (Macaca mulatta). J Pharmacol Exp Ther. 1988 Apr;245(1):211-5. PubMed PMID: 3361442. 12: Sutton TJ, Luke JS, Jones HB. Red cell haemolysis induced by SK&F 95018--a combined vasodilator and beta-adrenoceptor antagonist. Hum Toxicol. 1988 May;7(3):243-8. PubMed PMID: 3391620. 13: Hieble JP, Sulpizio AC, Gutzait L, Gombar CT. Cardiovascular effects of SK&F 104078, a novel alpha-adrenoceptor antagonist, in normotensive and hypertensive rats. J Cardiovasc Pharmacol. 1990 May;15(5):845-52. PubMed PMID: 1692947. 14: Dutta A, Singh N. Surfactant-modified bentonite clays: preparation, characterization, and atrazine removal. Environ Sci Pollut Res Int. 2015 Mar;22(5):3876-85. doi: 10.1007/s11356-014-3656-3. Epub 2014 Oct 3. PubMed PMID: 25273519. 15: Weichman BM, Wasserman MA, Gleason JG. SK&F 88046: a unique pharmacologic antagonist of bronchoconstriction induced by leukotriene D4, thromboxane and prostaglandins F2 alpha and D2 in vitro. J Pharmacol Exp Ther. 1984 Jan;228(1):128-32. PubMed PMID: 6582266. 16: Marshall PJ, Griswold DE, Breton J, Webb EF, Hillegass LM, Sarau HM, Newton J Jr, Lee JC, Bender PE, Hanna N. Pharmacology of the pyrroloimidazole, SK&F 105809--I. Inhibition of inflammatory cytokine production and of 5-lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1991 Jul 25;42(4):813-24. PubMed PMID: 1907824. 17: Brocks DR, Freed MI, Martin DE, Sellers TS, Mehdi N, Citerone DR, Boppana V, Levitt B, Davies BE, Nemunaitis J, Jorkasky DK. Interspecies pharmacokinetics of a novel hematoregulatory peptide (SK&F 107647) in rats, dogs, and oncologic patients. Pharm Res. 1996 May;13(5):794-7. PubMed PMID: 8860439. 18: Matthews WD, Macia RA, Beckeringh JJ, DeMarinis RM, de Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, van Zwieten PA. Calcium utilization in the vasoconstriction to enantiomers of SK&F 89748-A. J Pharmacol Exp Ther. 1985 Feb;232(2):330-6. PubMed PMID: 2857195. 19: Olivera DL, Esser KM, Lee JC, Greig RG, Badger AM. Beneficial effects of SK&F 105809, a novel cytokine-suppressive agent, in murine models of endotoxin shock. Circ Shock. 1992 Aug;37(4):301-6. PubMed PMID: 1446388. 20: Hieble JP, Sulpizio AC, Sarau HM, Flaim KE, Blumberg AL, McCafferty JP, Zeid RL. SK&F 89124, a potent and selective agonist at prejunctional dopamine receptors. Fundam Clin Pharmacol. 1989;3(6):621-42. PubMed PMID: 2575569.