MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 597641 | Name: Tilarginine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tilarginine is a competitive inhibitor of nitric oxide synthetase.

Chemical Structure

Tilarginine
CAS#17035-90-4

Theoretical Analysis

MedKoo Cat#: 597641

Name: Tilarginine

CAS#: 17035-90-4

Chemical Formula: C7H16N4O2

Exact Mass: 188.1273

Molecular Weight: 188.23

Elemental Analysis: C, 44.67; H, 8.57; N, 29.77; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Tilarginine; omega-N-Methylarginine; 546C88; L-NMMA; N-Methylarginine;
IUPAC/Chemical Name
Nw-methyl-L-arginine
InChi Key
NTNWOCRCBQPEKQ-YFKPBYRVSA-N
InChi Code
InChI=1S/C7H16N4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11)/t5-/m0/s1
SMILES Code
N[C@@H](CCCNC(NC)=N)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 188.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Firger J. Nitric Oxide Inhibitors Hit Target for Triple-Negative Breast Cancer. J Natl Cancer Inst. 2015 Aug 4;107(8). pii: djv235. doi: 10.1093/jnci/djv235. Print 2015 Aug. PubMed PMID: 26243205; PubMed Central PMCID: PMC4609569. 2: Sand CA, Hobbs AJ. The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer? Vascul Pharmacol. 2016 Feb;77:35-7. doi: 10.1016/j.vph.2015.10.008. Epub 2015 Nov 7. Review. PubMed PMID: 26556765. 3: Howes LG, Brillante DG. Expert opinion on tilarginine in the treatment of shock. Expert Opin Investig Drugs. 2008 Oct;17(10):1573-80. doi: 10.1517/13543784.17.10.1573 . Review. PubMed PMID: 18808317. 4: Bech JN, Aagaard NK, Pedersen RS, Sorensen TB, Vilstrup H, Pedersen EB. Renal effects of NO-inhibition in patients with cirrhosis vs. healthy controls: a randomized placebo-controlled crossover study. Liver Int. 2014 Feb;34(2):211-9. doi: 10.1111/liv.12233. Epub 2013 Jun 28. PubMed PMID: 23809512. 5: Martens-Lobenhoffer J, Bode-Böger SM, Clement B. First detection and quantification of N(δ)-monomethylarginine, a structural isomer of N(G)-monomethylarginine, in humans using MS(3). Anal Biochem. 2016 Jan 15;493:14-20. doi: 10.1016/j.ab.2015.10.001. Epub 2015 Oct 20. PubMed PMID: 26464121. 6: Wang S, Pan DX, Wang D, Wan P, Qiu DL, Jin QH. Nitric oxide facilitates active avoidance learning via enhancement of glutamate levels in the hippocampal dentate gyrus. Behav Brain Res. 2014 Sep 1;271:177-83. doi: 10.1016/j.bbr.2014.06.011. Epub 2014 Jun 13. PubMed PMID: 24933186. 7: Hou Y, Hu S, Jia S, Nawaratna G, Che D, Wang F, Bazer FW, Wu G. Whole-body synthesis of L-homoarginine in pigs and rats supplemented with L-arginine. Amino Acids. 2016 Apr;48(4):993-1001. doi: 10.1007/s00726-015-2145-4. Epub 2015 Dec 16. PubMed PMID: 26676627. 8: Stewart JM, Suggs M, Merchant S, Sutton R, Terilli C, Visintainer P, Medow MS. Postsynaptic α1-Adrenergic Vasoconstriction Is Impaired in Young Patients With Vasovagal Syncope and Is Corrected by Nitric Oxide Synthase Inhibition. Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e003828. doi: 10.1161/CIRCEP.115.003828. PubMed PMID: 27444639; PubMed Central PMCID: PMC4959809. 9: Muskiet MH, Tonneijck L, Smits MM, Kramer MH, Diamant M, Joles JA, van Raalte DH. Acute renal haemodynamic effects of glucagon-like peptide-1 receptor agonist exenatide in healthy overweight men. Diabetes Obes Metab. 2016 Feb;18(2):178-85. doi: 10.1111/dom.12601. Epub 2016 Jan 5. PubMed PMID: 26636423. 10: Jung CS, Lange B, Zimmermann M, Seifert V. Role of endogenous monomethylated L-arginine (L-NMMA) after subarachnoid hemorrhage. Neurol Res. 2013 Sep;35(7):709-12. doi: 10.1179/1743132813Y.0000000194. Epub 2013 Apr 12. PubMed PMID: 23582621. 11: Linz TH, Lunte SM. Heat-assisted extraction for the determination of methylarginines in serum by CE. Electrophoresis. 2013 Jun;34(11):1693-700. doi: 10.1002/elps.201200567. PubMed PMID: 23417924; PubMed Central PMCID: PMC3744101. 12: Bech JN, Starklint J, Bentzen H, Nyvad O, Pedersen EB. Renal and hormonal effects of systemic nitric oxide inhibition in patients with congestive heart failure and in healthy control subjects. J Card Fail. 2013 Nov;19(11):776-85. doi: 10.1016/j.cardfail.2013.10.001. Epub 2013 Oct 9. PubMed PMID: 24263123. 13: Zena LA, Gargaglioni LH, Bícego KC. Role of brain nitric oxide in the cardiovascular control of bullfrogs. Comp Biochem Physiol A Mol Integr Physiol. 2013 Jun;165(2):263-71. doi: 10.1016/j.cbpa.2013.03.020. Epub 2013 Mar 26. PubMed PMID: 23538225. 14: Jiao J, Zhou B, Zhu X, Gao Z, Liang Y. Fusaric acid induction of programmed cell death modulated through nitric oxide signalling in tobacco suspension cells. Planta. 2013 Oct;238(4):727-37. doi: 10.1007/s00425-013-1928-7. Epub 2013 Jul 10. PubMed PMID: 23838885. 15: Larsen T, Mose FH, Bech JN, Pedersen EB. Effect of nitric oxide inhibition on blood pressure and renal sodium handling: a dose-response study in healthy man. Clin Exp Hypertens. 2012;34(8):567-74. doi: 10.3109/10641963.2012.681727. Epub 2012 May 4. PubMed PMID: 22559218. 16: Cooke JP, Ghebremariam YT. DDAH says NO to ADMA. Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1462-4. doi: 10.1161/ATVBAHA.111.228833. PubMed PMID: 21677286; PubMed Central PMCID: PMC3132190. 17: Saito Y, Sawa T, Yoshitake J, Ito C, Fujii S, Akaike T, Arimoto H. Nitric oxide promotes recycling of 8-nitro-cGMP, a cytoprotective mediator, into intact cGMP in cells. Mol Biosyst. 2012 Nov;8(11):2909-15. doi: 10.1039/c2mb25189b. Epub 2012 Aug 14. PubMed PMID: 22892818. 18: Lee KS, Lee DK, Jeoung D, Lee H, Choe J, Ha KS, Won MH, Kwon YG, Kim YM. Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization. Biochem Biophys Res Commun. 2012 Feb 3;418(1):49-55. doi: 10.1016/j.bbrc.2011.12.123. Epub 2012 Jan 3. PubMed PMID: 22240022. 19: Schindler C, Leuschner S, Schwanebeck U, Kirch W. Characterization of local vascular effects of the nitric oxide inhibitor NG-monomethyl-L-arginine on dorsal hand veins. J Clin Pharmacol. 2012 Jun;52(6):859-69. doi: 10.1177/0091270011406277. Epub 2011 May 12. PubMed PMID: 21566204. 20: Cracowski JL, Roustit M. Pharmacology of the human skin microcirculation. Microvasc Res. 2010 Jul;80(1):1. doi: 10.1016/j.mvr.2010.03.005. Epub 2010 Mar 18. PubMed PMID: 20303359.