Synonym
Acth (1-4); (1-4) Corticotropin;
IUPAC/Chemical Name
L-seryl-L-tyrosyl-L-seryl-L-methionine
InChi Key
GTYVWTFUSMUWHM-VGWMRTNUSA-N
InChi Code
InChI=1S/C20H30N4O8S/c1-33-7-6-14(20(31)32)22-19(30)16(10-26)24-18(29)15(23-17(28)13(21)9-25)8-11-2-4-12(27)5-3-11/h2-5,13-16,25-27H,6-10,21H2,1H3,(H,22,30)(H,23,28)(H,24,29)(H,31,32)/t13-,14-,15-,16-/m0/s1
SMILES Code
CSCC[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CC=C(O)C=C1)NC([C@H](CO)N)=O)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
486.54
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: De Graan PN, Spruijt BM, Eberle AN, Girard J, Gispen WH. ACTH1-4 potentiates alpha-MSH-induced melanophore dispersion and excessive grooming. Peptides. 1986 Jan-Feb;7(1):1-4. PubMed PMID: 3012487.
2: Volosin M, Cancela L, Molina V. Influence of adrenocorticotrophic hormone on the behaviour in the swim test of rats treated chronically with desipramine. J Pharm Pharmacol. 1988 Jan;40(1):74-6. PubMed PMID: 2896786.
3: Neidle A, Reith ME. The degradation of adrenocorticotrophic hormone-(1-4) by mouse brain cytosol. Arch Biochem Biophys. 1980 Aug;203(1):288-95. PubMed PMID: 6250487.
4: Miller LJ, Moore FL. Intracranial administration of corticotropin-like peptides increases incidence of amphibian reproductive behavior. Peptides. 1983 Sep-Oct;4(5):729-33. PubMed PMID: 6318203.
5: Cehovic G, Cassonnet P. [Action of small peptides, fragments of ACTH on the incorporation of P32 in brain proteins in vitro]. C R Acad Sci III. 1984;298(7):191-4. French. PubMed PMID: 6324969.
6: Meyer ME, Bohus B. The modulation of the dorsal immobility response in the adult male Wistar rat: the opposite effects of ACTH4-10 and [D-Phe7]ACTH4-10. Behav Neural Biol. 1983 Jul;38(2):194-204. PubMed PMID: 6314984.
7: Gomar MD, Fernández B, Del Aguila CM, Castillo JL, Escames G, Acuña-Castroviejo D. Participation of ACTH1-10 and ACTH4-10 on the melatonin modulation of benzodiazepine receptors in rat cerebral cortex. Experientia. 1995 Mar 15;51(3):209-12. PubMed PMID: 7698280.
8: Wan R, Diamant M, de Jong W, de Wied D. Differential effects of ACTH4-10, DG-AVP, and DG-OXT on heart rate and passive avoidance behavior in rats. Physiol Behav. 1992 Mar;51(3):507-13. PubMed PMID: 1326112.
