Septide | CAS#79775-19-2 | NK1 receptor agonist

MedKoo Cat#: 597608 | Name: Septide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Septide is an agonist for the NK1 receptor acting at a site distinct from substance P.

Chemical Structure

Septide

CAS#79775-19-2

Theoretical Analysis

MedKoo Cat#: 597608

Name: Septide

CAS#: 79775-19-2

Chemical Formula: C39H53N7O7S

Exact Mass: 763.3727

Molecular Weight: 763.95

Elemental Analysis: C, 61.32; H, 6.99; N, 12.83; O, 14.66; S, 4.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Septide; 6-Glp-9-pro-substance P (6-11); Substance P (6-11), pyroglutamyl(6)-proline(9)-;

IUPAC/Chemical Name

(S)-N-((S)-1-(((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-1-(((S)-5-oxopyrrolidine-2-carbonyl)-L-phenylalanyl-L-phenylalanyl)pyrrolidine-2-carboxamide

InChi Key

UUZURPUIMYJOIL-JNRWAQIZSA-N

InChi Code

InChI=1S/C39H53N7O7S/c1-24(2)21-29(36(50)42-27(34(40)48)18-20-54-3)44-38(52)32-15-10-19-46(32)39(53)31(23-26-13-8-5-9-14-26)45-37(51)30(22-25-11-6-4-7-12-25)43-35(49)28-16-17-33(47)41-28/h4-9,11-14,24,27-32H,10,15-23H2,1-3H3,(H2,40,48)(H,41,47)(H,42,50)(H,43,49)(H,44,52)(H,45,51)/t27-,28-,29-,30-,31-,32-/m0/s1

SMILES Code

CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC([C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H](CC3=CC=CC=C3)NC([C@H](CC4)NC4=O)=O)=O)=O)CCC1)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 763.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Torrens Y, Beaujouan JC, Saffroy M, Glowinski J. Involvement of septide-sensitive tachykinin receptors in inositol phospholipid hydrolysis in the rat urinary bladder. Peptides. 1995;16(4):587-94. PubMed PMID: 7479288. 2: Ahluwalia A, Giuliani S, Maggi CA. Demonstration of a 'septide-sensitive' inflammatory response in rat skin. Br J Pharmacol. 1995 Oct;116(4):2170-4. PubMed PMID: 8564245; PubMed Central PMCID: PMC1908977. 3: Huleux C, Berthier A, Rossignol B, Dreux C. A "septide-sensitive" receptor is not involved in tachykinin-mediated secretory and inositol phosphate responses in rat parotid gland: are several transduction pathways involved after the stimulation of the NK1 receptor? J Neurochem. 1998 Feb;70(2):858-64. PubMed PMID: 9453583. 4: Ricciardolo FL, Trevisani M, Geppetti P, Nadel JA, Amadesi S, Bertrand C. Role of nitric oxide and septide-insensitive NK(1) receptors in bronchoconstriction induced by aerosolised neurokinin A in guinea-pigs. Br J Pharmacol. 2000 Mar;129(5):915-20. PubMed PMID: 10696090; PubMed Central PMCID: PMC1571918. 5: Hastrup H, Schwartz TW. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis. FEBS Lett. 1996 Dec 16;399(3):264-6. PubMed PMID: 8985159. 6: Menéndez L, Hidalgo A, Baamonde A. Spinal calmodulin inhibitors reduce N-methyl-D-aspartate- and septide-induced nociceptive behavior. Eur J Pharmacol. 1997 Sep 17;335(1):9-14. PubMed PMID: 9371540. 7: Figini M, Emanueli C, Bertrand C, Javdan P, Geppetti P. Evidence that tachykinins relax the guinea-pig trachea via nitric oxide release and by stimulation of a septide-insensitive NK1 receptor. Br J Pharmacol. 1996 Mar;117(6):1270-6. PubMed PMID: 8882625; PubMed Central PMCID: PMC1909790. 8: Gauchy C, Desban M, Glowinski J, Kemel ML. Distinct regulations by septide and the neurokinin-1 tachykinin receptor agonist [pro9]substance P of the N-methyl-D-aspartate-evoked release of dopamine in striosome- and matrix-enriched areas of the rat striatum. Neuroscience. 1996 Aug;73(4):929-39. PubMed PMID: 8809812. 9: Beaujouan JC, Saffroy M, Torrens Y, Sagan S, Glowinski J. Pharmacological characterization of tachykinin septide-sensitive binding sites in the rat submaxillary gland. Peptides. 1999 Nov;20(11):1347-52. PubMed PMID: 10612450. 10: Pradier L, Ménager J, Le Guern J, Bock MD, Heuillet E, Fardin V, Garret C, Doble A, Mayaux JF. Septide: an agonist for the NK1 receptor acting at a site distinct from substance P. Mol Pharmacol. 1994 Feb;45(2):287-93. PubMed PMID: 7509440. 11: Sagan S, Beaujouan JC, Torrens Y, Saffroy M, Chassaing G, Glowinski J, Lavielle S. High affinity binding of [3H]propionyl-[Met(O2)11]substance P(7-11), a tritiated septide-like peptide, in Chinese hamster ovary cells expressing human neurokinin-1 receptors and in rat submandibular glands. Mol Pharmacol. 1997 Jul;52(1):120-7. PubMed PMID: 9224821. 12: Cellier E, Barbot L, Iyengar S, Couture R. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28. PubMed PMID: 10401563; PubMed Central PMCID: PMC1566074. 13: Alvarez-Vega M, Baamonde A, Gutiérrez M, Hidalgo A, Menéndez L. Comparison of the effects of calmidazolium, morphine and bupivacaine on N-methyl-D-aspartate- and septide-induced nociceptive behaviour. Naunyn Schmiedebergs Arch Pharmacol. 1998 Dec;358(6):628-34. PubMed PMID: 9879721. 14: Burcher E, Stamatakos C. Septide but not substance P stimulates inhibitory neurons in guinea-pig ileum. Eur J Pharmacol. 1994 Jun 13;258(3):R9-10. PubMed PMID: 7522175. 15: Torrens Y, Beaujouan JC, Saffroy M, Glowinski J. Further evidence for the presence of "septide-sensitive" tachykinin binding sites in tissues possessing solely NK(1) tachykinin receptors. Biochem Biophys Res Commun. 2000 Apr 13;270(2):668-72. PubMed PMID: 10753681. 16: Glowinski J. The 'septide-sensitive' tachykinin receptor: still an enigma. Trends Pharmacol Sci. 1995 Nov;16(11):365-7. Review. PubMed PMID: 8578604. 17: Zeng XP, Burcher E. Use of selective antagonists for further characterization of tachykinin NK-2, NK-1 and possible "septide-selective" receptors in guinea pig bronchus. J Pharmacol Exp Ther. 1994 Sep;270(3):1295-300. PubMed PMID: 7523658. 18: Palma C, Goso C, Manzini S. Different susceptibility to neurokinin 1 receptor antagonists of substance P and septide-induced interleukin-6 release from U373 MG human astrocytoma cell line. Neurosci Lett. 1994 Apr 25;171(1-2):221-4. PubMed PMID: 7521949. 19: Maggi CA, Patacchini R, Meini S, Giuliani S. Evidence for the presence of a septide-sensitive tachykinin receptor in the circular muscle of the guinea-pig ileum. Eur J Pharmacol. 1993 Apr 28;235(2-3):309-11. PubMed PMID: 7685292. 20: Boni P, Maggi CA, Evangelista S. In vivo evidence for the activation of a septide-sensitive tachykinin receptor in guinea pig bronchoconstriction. Life Sci. 1994;54(19):PL327-32. PubMed PMID: 7514707.