KBH-A42 | CAS#798543-50-7 | deacetylase inhibitor

MedKoo Cat#: 563241 | Name: KBH-A42

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KBH-A42 is a histone deacetylase inhibitor.

Chemical Structure

KBH-A42

CAS#798543-50-7

Theoretical Analysis

MedKoo Cat#: 563241

Name: KBH-A42

CAS#: 798543-50-7

Chemical Formula: C17H22N2O3

Exact Mass: 302.1630

Molecular Weight: 302.37

Elemental Analysis: C, 67.53; H, 7.33; N, 9.26; O, 15.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KBH-A42; KBH A42; KBHA42; KBH-A 42; KBH A 42; KBH-A-42;

IUPAC/Chemical Name

N-Hydroxy-3-[2-oxo-1-(3-phenylpropyl)-1,2,5,6-tetrahydropyridin-3-yl]propionamide

InChi Key

QVZVOPUKMAJJHD-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H22N2O3/c20-16(18-22)11-10-15-9-5-13-19(17(15)21)12-4-8-14-6-2-1-3-7-14/h1-3,6-7,9,22H,4-5,8,10-13H2,(H,18,20)

SMILES Code

O=C(NO)CCC1=CCCN(CCCC2=CC=CC=C2)C1=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 302.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kang MR, Kang JS, Yang JW, Kim BG, Kim JA, Jo YN, Lee K, Lee CW, Lee KH, Yun J, Kim HM, Han G, Kang JS, Park SK. Gene expression profiling of KBH-A42, a novel histone deacetylase inhibitor, in human leukemia and bladder cancer cell lines. Oncol Lett. 2012 Jan;3(1):113-118. Epub 2011 Sep 28. PubMed PMID: 22740865; PubMed Central PMCID: PMC3362651. 2: Kang MR, Lee K, Kang JS, Lee CW, Lee KH, Kim JH, Yang JW, Kim BG, Han G, Kang JS, Park SK, Kim HM. KBH-A42, a histone deacetylase inhibitor, inhibits the growth of doxorubicin-resistant leukemia cells expressing P-glycoprotein. Oncol Rep. 2010 Mar;23(3):801-9. PubMed PMID: 20127023. 3: Kang MR, Kang JS, Han SB, Kim JH, Kim DM, Lee K, Lee CW, Lee KH, Lee CH, Han G, Kang JS, Kim HM, Park SK. A novel delta-lactam-based histone deacetylase inhibitor, KBH-A42, induces cell cycle arrest and apoptosis in colon cancer cells. Biochem Pharmacol. 2009 Sep 1;78(5):486-94. doi: 10.1016/j.bcp.2009.05.010. Epub 2009 May 13. PubMed PMID: 19445901. 4: Choi Y, Park SK, Kim HM, Kang JS, Yoon YD, Han SB, Han JW, Yang JS, Han G. Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. Exp Mol Med. 2008 Oct 31;40(5):574-81. PubMed PMID: 18985016; PubMed Central PMCID: PMC2679350.