Cgp 29287 | CAS#93287-54-8 | renin inhibitor

MedKoo Cat#: 597585 | Name: Cgp 29287

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgp 29287 is a primate-specific renin inhibitor with prolonged duration of action.

Chemical Structure

Cgp 29287

CAS#93287-54-8

Theoretical Analysis

MedKoo Cat#: 597585

Name: Cgp 29287

CAS#: 93287-54-8

Chemical Formula: C72H110N20O15

Exact Mass: 1494.8460

Molecular Weight: 1495.79

Elemental Analysis: C, 57.81; H, 7.41; N, 18.73; O, 16.04

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Cgp 29287; Cgp-29287; Cgp29287; Cgp-29,287; Cgp 29,287; Cgp29,287;

IUPAC/Chemical Name

methyl N2-((3S,4S)-4-((S)-2-((S)-2-((S)-1-(((benzyloxy)carbonyl)-L-arginyl-L-arginyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-(1H-imidazol-4-yl)propanamido)-3-hydroxy-6-methylheptanoyl)-L-isoleucyl-L-histidyl-N6-(tert-butoxycarbonyl)-L-lysinate

InChi Key

DLAHCJHYEAZDLE-VRYQDWSQSA-N

InChi Code

InChI=1S/C72H110N20O15/c1-9-44(4)59(65(100)89-55(36-48-39-78-42-83-48)62(97)85-51(67(102)105-8)25-16-17-29-81-70(103)107-72(5,6)7)91-58(94)37-57(93)52(33-43(2)3)86-63(98)54(35-47-38-77-41-82-47)87-61(96)53(34-45-21-12-10-13-22-45)88-64(99)56-28-20-32-92(56)66(101)50(27-19-31-80-69(75)76)84-60(95)49(26-18-30-79-68(73)74)90-71(104)106-40-46-23-14-11-15-24-46/h10-15,21-24,38-39,41-44,49-57,59,93H,9,16-20,25-37,40H2,1-8H3,(H,77,82)(H,78,83)(H,81,103)(H,84,95)(H,85,97)(H,86,98)(H,87,96)(H,88,99)(H,89,100)(H,90,104)(H,91,94)(H4,73,74,79)(H4,75,76,80)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-/m0/s1

SMILES Code

O=C(OC)[C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC1=CNC=N1)NC([C@H]([C@@H](C)CC)NC(C[C@H](O)[C@@H](NC([C@H](CC2=CNC=N2)NC([C@H](CC3=CC=CC=C3)NC([C@H]4N(C([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(OCC5=CC=CC=C5)=O)=O)=O)CCC4)=O)=O)=O)CC(C)C)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,495.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Samani NJ, Cumin F, Kelly M, Wood JM. Expression of components of the RAS during prolonged blockade at different levels in primates. Am J Physiol. 1994 Oct;267(4 Pt 1):E612-9. PubMed PMID: 7943312. 2: Humke U, Levens N, Wood J, Hofbauer K. Responses to renin inhibition in conscious primates. Am J Physiol. 1991 Jul;261(1 Pt 2):F179-86. PubMed PMID: 1907105. 3: Nussberger J, Brunner DB, Waeber B, Brunner HR. In vitro renin inhibition to prevent generation of angiotensins during determination of angiotensin I and II. Life Sci. 1988;42(17):1683-8. PubMed PMID: 2835564. 4: de Gasparo MM, Wood JM, Heusser CH. Mechanism of inhibition of human renin by monoclonal antibodies. Hypertension. 1988 Mar;11(3):209-16. PubMed PMID: 3280480. 5: Wood JM, Jobber RA, Baum HP, Hofbauer KG. Comparison of chronic inhibition of renin and converting enzyme in the marmoset. Clin Exp Hypertens A. 1987;9(2-3):337-43. PubMed PMID: 3038392. 6: Wood JM, Baum HP, Carleton J, Dzau VJ. Inhibition of renin-like activity in marmoset tissues by the renin inhibitor CGP 29 287. J Hypertens Suppl. 1987 Jul;5(2):S67-9. PubMed PMID: 3116182. 7: Wood JM, Gulati N, Forgiarini P, Fuhrer W, Hofbauer KG. Effects of a specific and long-acting renin inhibitor in the marmoset. Hypertension. 1985 Sep-Oct;7(5):797-803. PubMed PMID: 3928488. 8: Wood JM, Baum HP, Forgiarini P, Gulati N, Jobber RA, Neisius D, Hofbauer KG. Haemodynamic effects of acute and chronic renin inhibition in marmosets. J Hypertens Suppl. 1989 Apr;7(2):S37-42. PubMed PMID: 2547039. 9: Wood JM, Baum HP, Jobber RA, Neisius D. Sustained reduction in blood pressure during chronic administration of a renin inhibitor to normotensive marmosets. J Cardiovasc Pharmacol. 1987;10 Suppl 7:S96-8. PubMed PMID: 2485073. 10: Wood JM, Jobber RA, Baum HP, de Gasparo M, Nussberger J. Biochemical effects of prolonged renin inhibition in marmosets. J Hypertens. 1989 Aug;7(8):615-8. PubMed PMID: 2681408. 11: Neisius D, Wood JM, Hofbauer KG. Renal vasodilatation after inhibition of renin or converting enzyme in marmoset. Am J Physiol. 1986 Nov;251(5 Pt 2):H897-902. PubMed PMID: 3022608. 12: Hofbauer KG, Fuhrer W, Heusser C, Wood JM. Comparison of different drug interference with the renin-angiotensin system. J Cardiovasc Pharmacol. 1985;7 Suppl 4:S62-8. PubMed PMID: 2412016. 13: Hofbauer KG, Wood JM, Gulati N, Heusser C, Ménard J. Increased plasma renin during renin inhibition. Studies with a novel immunoassay. Hypertension. 1985 May-Jun;7(3 Pt 2):I61-5. PubMed PMID: 2987126. 14: Neisius D, Wood JM. Antihypertensive effect of a renin inhibitor in marmosets with a segmental renal infarction. J Hypertens. 1987 Dec;5(6):721-5. PubMed PMID: 2828470. 15: Song K, Miyazaki M, Okunishi H, Ishii K, Takai S, Shiota N, Kim S, Mendelsohn FA. Localization and quantitation of active renin in monkey kidney by radioinhibitor binding and in vitro autoradiography. Am J Hypertens. 1994 Jun;7(6):529-35. PubMed PMID: 7917151.