MedKoo Cat#: 563234 | Name: CVT-11127
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CVT-11127 is an inhibitor of StearoylCoA Desaturase-1 (SCD1).

Chemical Structure

CVT-11127
CVT-11127
CAS#1018674-83-3

Theoretical Analysis

MedKoo Cat#: 563234

Name: CVT-11127

CAS#: 1018674-83-3

Chemical Formula: C25H23Cl2N5O3

Exact Mass: 511.1178

Molecular Weight: 512.39

Elemental Analysis: C, 58.60; H, 4.52; Cl, 13.84; N, 13.67; O, 9.37

Price and Availability

Size Price Availability Quantity
25mg USD 550.00 2 Weeks
100mg USD 1,950.00 2 Weeks
1g USD 4,950.00 2 Weeks
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Related CAS #
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Synonym
CVT-11127; CVT 11127; CVT11127; FMK13918; FMK-13918; FMK 13918
IUPAC/Chemical Name
N-(2-(6-(3,4-Dichlorobenzylamino)-2-(4-methoxyphenyl)-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl) acetamide
InChi Key
PVTIQVJHZDSETN-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H23Cl2N5O3/c1-15(33)28-11-12-32-24-21(30-23(25(32)34)17-4-6-18(35-2)7-5-17)9-10-22(31-24)29-14-16-3-8-19(26)20(27)13-16/h3-10,13H,11-12,14H2,1-2H3,(H,28,33)(H,29,31)
SMILES Code
CC(NCCN1C2=NC(NCC3=CC=C(Cl)C(Cl)=C3)=CC=C2N=C(C4=CC=C(OC)C=C4)C1=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 512.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nashed M, Chisholm JW, Igal RA. Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med (Maywood). 2012 Sep;237(9):1007-17. Epub 2012 Sep 3. PubMed PMID: 22946088. 2: Hess D, Chisholm JW, Igal RA. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010 Jun 30;5(6):e11394. doi: 10.1371/journal.pone.0011394. PubMed PMID: 20613975; PubMed Central PMCID: PMC2894866.