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MedKoo Cat#: 597557 | Name: Interleukin-1beta (163-171)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Interleukin-1beta (163-171) is a nonapeptide which has immunostimulating activity in vivo.

Chemical Structure

Interleukin-1beta (163-171)
Interleukin-1beta (163-171)
CAS#106021-96-9

Theoretical Analysis

MedKoo Cat#: 597557

Name: Interleukin-1beta (163-171)

CAS#: 106021-96-9

Chemical Formula: C39H64N12O19

Exact Mass: 1004.4411

Molecular Weight: 1005.00

Elemental Analysis: C, 46.61; H, 6.42; N, 16.72; O, 30.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Interleukin-1beta (163-171); IL-1beta (163-171);
IUPAC/Chemical Name
L-valyl-L-glutaminylglycyl-L-glutamyl-L-glutamyl-L-seryl-L-asparaginyl-L-aspartyl-L-lysine
InChi Key
NIXBZDOQHRZFDR-OEWCNXHOSA-N
InChi Code
InChI=1S/C39H64N12O19/c1-17(2)31(43)38(68)47-18(6-9-25(41)53)32(62)44-15-27(55)45-19(7-10-28(56)57)33(63)46-20(8-11-29(58)59)34(64)51-24(16-52)37(67)49-22(13-26(42)54)35(65)50-23(14-30(60)61)36(66)48-21(39(69)70)5-3-4-12-40/h17-24,31,52H,3-16,40,43H2,1-2H3,(H2,41,53)(H2,42,54)(H,44,62)(H,45,55)(H,46,63)(H,47,68)(H,48,66)(H,49,67)(H,50,65)(H,51,64)(H,56,57)(H,58,59)(H,60,61)(H,69,70)/t18-,19-,20-,21-,22-,23-,24-,31-/m0/s1
SMILES Code
O=C(O)[C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@H](CCC(N)=O)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,005.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Boraschi D, Ghiara P, Scapigliati G, Villa L, Sette A, Tagliabue A. Binding and internalization of the 163-171 fragment of human IL-1 beta. Cytokine. 1992 May;4(3):201-4. PubMed PMID: 1386756. 2: Nencioni L, Villa L, Tagliabue A, Antoni G, Presentini R, Perin F, Silvestri S, Boraschi D. In vivo immunostimulating activity of the 163-171 peptide of human IL-1 beta. J Immunol. 1987 Aug 1;139(3):800-4. PubMed PMID: 2955051. 3: Farhan J, Al-Shobaili HA, Zafar U, Al Salloom A, Meki AR, Rasheed Z. Interleukin-6: a possible inflammatory link between vitiligo and type 1 diabetes. Br J Biomed Sci. 2014;71(4):151-7. PubMed PMID: 25562992. 4: Boraschi D, Ghiara P, Villa L, Antoni G, Tagliabue A. The 163-171 peptide of human IL-1 beta. Prog Clin Biol Res. 1990;349:365-74. PubMed PMID: 2144645. 5: Nencioni L, Villa L, Tagliabue A, Boraschi D. Adjuvant activity of the 163-171 peptide of human IL-1 beta administered through different routes. Lymphokine Res. 1987 Fall;6(4):335-9. PubMed PMID: 3501509. 6: Pessina GP, Bocci V, Nicoletti C, Becherucci C, Presentini R, Parente L, Villa L, Tagliabue A, Boraschi D. Metabolic behavior and distribution of the synthetic nonapeptide fragment 163-171 of human IL-1 beta. Lymphokine Res. 1990 Fall;9(3):371-9. PubMed PMID: 2398742. 7: Cai Z, Shen L, He B. Moving with and beyond CANTOS: How to put out the fire of inflammation in atherosclerosis? Int J Cardiol. 2015 Sep 15;195:45-7. doi: 10.1016/j.ijcard.2015.05.123. Epub 2015 May 21. Review. PubMed PMID: 26016812. 8: Tagliabue A, Antoni G, Boraschi D. Defining agonist peptides of human interleukin-1 beta. Lymphokine Res. 1989 Fall;8(3):311-5. PubMed PMID: 2789323. 9: Mulhall KJ, Curtin WA, Given HF. Inhibition of polymethylmethacrylate particle-induced monocyte activation and IL-1beta and TNF-alpha expression by the antioxidant agent N-acetylcysteine. Acta Orthop Scand. 2002 Apr;73(2):206-12. PubMed PMID: 12079021. 10: Ketlinskiĭ SA, Kalinina NM, Tsvetkova SN, Rakhmanova AG, Maslov VN, Khaldeeva NA. [Tumor necrosis factor-alpha and interleukin-1beta in the blood plasma of patients with HIV infection]. Vestn Ross Akad Med Nauk. 1992;(9-10):36-41. Review. Russian. PubMed PMID: 1283718. 11: Li S, Ballou LR, Morham SG, Blatteis CM. Cyclooxygenase-2 mediates the febrile response of mice to interleukin-1beta. Brain Res. 2001 Aug 10;910(1-2):163-73. PubMed PMID: 11489266. 12: Kolyada AY, Madias NE. Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells. Mol Med. 2001 May;7(5):329-43. PubMed PMID: 11474579; PubMed Central PMCID: PMC1950040. 13: Siddiqui MZ, Sharma AK, Kumar S, Kumar A, Bhat PN. Conformation of a T-cell stimulating peptide of interleukin-1 beta protein: circular dichroism studies. Int J Biol Macromol. 1994 Oct;16(5):259-63. PubMed PMID: 7534472. 14: Miller MJ, Ahmed S, Bobrowski P, Haqqi TM. The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006 Apr 7;6:13. PubMed PMID: 16603065; PubMed Central PMCID: PMC1456997. 15: Yang J, Hu Z, Xu Y, Shen J, Niu J, Hu X, Guo J, Wei Q, Wang X, Shen H. Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett. 2004 Nov 25;215(2):191-8. PubMed PMID: 15488638. 16: Buono RJ, Ferraro TN, O'Connor MJ, Sperling MR, Ryan SG, Scattergood T, Mulholland N, Gilmore J, Lohoff FW, Berrettini WH. Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy. Epilepsia. 2001 Jun;42(6):782-4. PubMed PMID: 11422336. 17: Cominelli F, Nast CC, Llerena R, Dinarello CA, Zipser RD. Interleukin 1 suppresses inflammation in rabbit colitis. Mediation by endogenous prostaglandins. J Clin Invest. 1990 Feb;85(2):582-6. PubMed PMID: 2298922; PubMed Central PMCID: PMC296462. 18: Li L, Ren F, Yun Z, An Y, Wang C, Yan X. Determination of the effects of lactoferrin in a preclinical mouse model of experimental colitis. Mol Med Rep. 2013 Oct;8(4):1125-9. doi: 10.3892/mmr.2013.1632. Epub 2013 Aug 14. PubMed PMID: 23942946. 19: Wallace JL, Keenan CM, Mugridge KG, Parente L. Reduction of the severity of experimental gastric and duodenal ulceration by interleukin-1 beta. Eur J Pharmacol. 1990 Sep 21;186(2-3):279-84. PubMed PMID: 2289528. 20: Altomonte L, Zoli A, Mirone L, Scolieri P, Magaró M. Serum levels of interleukin-1b, tumour necrosis factor-a and interleukin-2 in rheumatoid arthritis. Correlation with disease activity. Clin Rheumatol. 1992 Jun;11(2):202-5. PubMed PMID: 1617893.