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MedKoo Cat#: 597552 | Name: Hemoregulatory peptide 5b

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hemoregulatory peptide 5b is a synthetic analog of granulocyte chalone; initially identified in extracts of rodent bone marrow and human leukocytes; monomer inhibits both formation of GM-CFC colonies and cytotoxic drug induced recruitment of murine CRU-S cells into active cell cycle; dimer has stimulatory activity.

Chemical Structure

Hemoregulatory peptide 5b
Hemoregulatory peptide 5b
CAS#84588-89-6

Theoretical Analysis

MedKoo Cat#: 597552

Name: Hemoregulatory peptide 5b

CAS#: 84588-89-6

Chemical Formula: C23H36N6O11S

Exact Mass: 604.2163

Molecular Weight: 604.63

Elemental Analysis: C, 45.69; H, 6.00; N, 13.90; O, 29.11; S, 5.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Hemoregulatory peptide 5b; hp 5B; Peedck; Pglu-glu-asp-cys-lys-OH; Glp-glu-asp-cys-lys-OH; SP1 Pentapeptide;
IUPAC/Chemical Name
((S)-5-oxopyrrolidine-2-carbonyl)-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine
InChi Key
WMMKLGOAKIPZJN-YTFOTSKYSA-N
InChi Code
InChI=1S/C23H36N6O11S/c24-8-2-1-3-13(23(39)40)27-22(38)15(10-41)29-21(37)14(9-18(33)34)28-20(36)12(5-7-17(31)32)26-19(35)11-4-6-16(30)25-11/h11-15,41H,1-10,24H2,(H,25,30)(H,26,35)(H,27,38)(H,28,36)(H,29,37)(H,31,32)(H,33,34)(H,39,40)/t11-,12-,13-,14-,15-/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@H](CS)NC([C@H](CC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC1)NC1=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 604.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kreja L, Hågå P, Muller-Bérat N, Laerum OD, Sletvold O, Paukovits WR. Effects of a hemoregulatory peptide (HP5b) on erythroid and myelopoietic colony formation in vitro. Scand J Haematol. 1986 Aug;37(2):79-86. PubMed PMID: 3764340. 2: Frostad S, Kalland T, Aakvaag A, Laerum OD. Hemoregulatory peptide (HP5b) dimer effects on normal and malignant cells in culture. Stem Cells. 1993 Jul;11(4):303-11. PubMed PMID: 8401253. 3: Paukovits JB, Rutter R, Ganglberger E, Karlic HI, Marian B, Paukovits WR. The hemoregulatory peptide pEEDCK may inhibit stem cell proliferation via hydropathic binding to antisense sequence motifs in interleukin-11 and other growth factors. Mol Pharmacol. 1999 Oct;56(4):665-74. PubMed PMID: 10496948. 4: Karlic H, Louda N, Pfeilstöcker M, Keil F, Lohninger A, Pittermann E, Paukovits J. Effect of the hemoregulatory peptide (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 and MIP-1alpha is reduced in bone marrow cultures from patients with chronic myeloid leukemia (CML). Stem Cells. 2001;19(4):321-8. PubMed PMID: 11463952. 5: Laerum OD, Frostad S, Tøn HI, Kamp D. The sequence of the hemoregulatory peptide is present in Gi alpha proteins. FEBS Lett. 1990 Aug 20;269(1):11-4. PubMed PMID: 2117550. 6: Laerum OD, Sletvold O, Bjerknes R, Eriksen JA, Johansen JH, Schanche JS, Tveterås T, Paukovits WR. The dimer of hemoregulatory peptide (HP5B) stimulates mouse and human myelopoiesis in vitro. Exp Hematol. 1988 May;16(4):274-80. PubMed PMID: 3258825. 7: Laerum OD, Aakvaag A, Frostad S, Kalland T, Langen P, Maurer HR. Selectivity of hemoregulatory peptide (HP5b) action in culture. Int J Cell Cloning. 1990 Nov;8(6):431-44. PubMed PMID: 2273297. 8: Laerum OD, Paukovits WR. Biological and chemical properties of the hemoregulatory peptide and possibilities for clinical applications. Pharmacol Ther. 1989;44(3):335-49. Review. PubMed PMID: 2519347. 9: Alisauskas RM, Goldenberg DM, Sharkey RM, Blumenthal RD. Reduction in the duration of myelotoxicity associated with radioimmunotherapy with infusions of the hemoregulatory peptide, HP5b in mice. Int J Cancer. 1997 Jan 27;70(3):323-9. PubMed PMID: 9033635. 10: Laerum OD, Paukovits WR. Peripheral blood leukocyte alterations in mice induced by a hemoregulatory pentapeptide (HP 5b). Leuk Res. 1985;9(8):1075-84. PubMed PMID: 3840221. 11: Laerum OD, Sletvod O, Bjerknes R, Paukovits WR. A synthetic hemoregulatory peptide (HP5B) inhibits human myelopoietic colony formation (CFU-GM) but not leukocyte phagocytosis in vitro. Eur J Haematol. 1987 Sep;39(3):259-66. PubMed PMID: 3678477. 12: Laerum OD, Paukovits WR. Modification of mouse hemopoietic cell proliferation in vivo by a hemoregulatory pentapeptide (HP 5b). Relation to circadian rhythms. Virchows Arch B Cell Pathol Incl Mol Pathol. 1984;46(4):333-48. PubMed PMID: 6150578. 13: Laerum OD, Paukovits WR. Modulation of murine hemopoiesis in vivo by a synthetic hemoregulatory pentapeptide (HP 5b). Differentiation. 1984;27(2):106-12. PubMed PMID: 6548197. 14: Pfeilstöcker M, Karlic H, Paukovits J, Anzenberger G, Louda N, Salamon J, Mühlberger H, Strobl H, Pittermann E, Heinz R. In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 on G alpha16-positive hematopoiesis. Leukemia. 1999 Apr;13(4):590-4. PubMed PMID: 10214866. 15: Veiby OP, Løvhaug D, Fjerdingstad H, Engelsen SJ. Indirect stimulation of hemopoiesis by hemoregulatory peptide (HP5b) dimer in murine long-term bone marrow cultures. Exp Hematol. 1992 Feb;20(2):192-5. PubMed PMID: 1544388. 16: Paukovits WR, Guigon M, Binder KA, Hergl A, Laerum OD, Schulte-Hermann R. Prevention of hematotoxic side effects of cytostatic drugs in mice by a synthetic hemoregulatory peptide. Cancer Res. 1990 Jan 15;50(2):328-32. PubMed PMID: 2295072. 17: Langen P, Schunck H, Hunger B, Schütt M, Laerum OD. Adherent-cell-dependent stimulation of CFU-GM by nucleobases, nucleosides, their analogues, and the hemoregulatory peptide dimer. Exp Hematol. 1992 Feb;20(2):196-200. PubMed PMID: 1544389. 18: Paukovits WR, Moser MH, Binder KA, Paukovits JB. Protection from arabinofuranosylcytosine and n-mustard-induced myelotoxicity using hemoregulatory peptide pGlu-Glu-Asp-Cys-Lys monomer and dimer. Blood. 1991 Mar 15;77(6):1313-9. PubMed PMID: 2001454. 19: Paukovits WR, Moser MH, Rutter R, Paukovits JB. Inhibition of hematopoietic stem cell proliferation by hemoregulatory peptide pyroGlu-Glu-Asp-Cys-Lys (pEEDCK) provides protection against short-term neutropenia and long-term damage. Ann N Y Acad Sci. 1991;628:92-104. PubMed PMID: 2069326. 20: King AG, Talmadge JE, Badger AM, Pelus LM. Regulation of colony-stimulating activity production from bone marrow stromal cells by the hematoregulatory peptide, HP-5. Exp Hematol. 1992 Feb;20(2):223-8. Erratum in: Exp Hematol 1992 May;20(4):531. PubMed PMID: 1544391.