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MedKoo Cat#: 558364 | Name: Rhodblock 3
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rhodblock 3 is a small molecule and potent inhibitor of the Rho pathway.

Chemical Structure

Rhodblock 3
Rhodblock 3
CAS#879564-86-0

Theoretical Analysis

MedKoo Cat#: 558364

Name: Rhodblock 3

CAS#: 879564-86-0

Chemical Formula: C11H10ClNO2

Exact Mass: 223.0400

Molecular Weight: 223.66

Elemental Analysis: C, 59.07; H, 4.51; Cl, 15.85; N, 6.26; O, 14.31

Price and Availability

Size Price Availability Quantity
5mg USD 295.00
25mg USD 750.00
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Related CAS #
No Data
Synonym
Rhodblock 3;
IUPAC/Chemical Name
2-(5-Chloro-6-methylbenzofuran-3-yl)-acetamide
InChi Key
DJJRJQKRSSUZIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H10ClNO2/c1-6-2-10-8(4-9(6)12)7(5-15-10)3-11(13)14/h2,4-5H,3H2,1H3,(H2,13,14)
SMILES Code
O=C(N)CC1=COC2=CC(C)=C(Cl)C=C12
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>3 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Rhodblock 3 is an inhibitor of Rho Kinase pathway. Rhodblock 3 acts upstream of Rok in Drosophila, resulting in the downregulation of Rok and inhibition of myosin phosphorylation. Rhodblock 3 inhibits phospho-MRLC localization as well as furrow localization of the septin Peanut and increased Peanut’s localization on microtubules but did not affect other proteins tested, such as Anillin.
In vitro activity:
This study discovered the molecules Rhodblock and identified their target as Rho kinase. Several Rhodblocks inhibited the correct localization of phosphorylated myosin light chain during cytokinesis. Rhodblocks differentially perturb Rho pathway proteins in cells and can be used to dissect the mechanism of the Rho pathway during cytokinesis. Reference: Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. https://pubmed.ncbi.nlm.nih.gov/20436488/
In vivo activity:
To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 223.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. Epub 2010 May 2. PMID: 20436488; PMCID: PMC2873065.
In vitro protocol:
1. Castoreno AB, Smurnyy Y, Torres AD, Vokes MS, Jones TR, Carpenter AE, Eggert US. Small molecules discovered in a pathway screen target the Rho pathway in cytokinesis. Nat Chem Biol. 2010 Jun;6(6):457-63. doi: 10.1038/nchembio.363. Epub 2010 May 2. PMID: 20436488; PMCID: PMC2873065.
In vivo protocol:
To be determined