AMPK activator D942 is a cell-permeable activator of AMPK. D942 is the first chemical to be identified that can increase the desiccation tolerance of an anhydrobiotic tardigrade. D942 and curcumin induced autophagy in cardiomyocytes through activating AMPK pathway or inhibiting mTOR signaling. Induction of autophagy by D942 and curcumin was the cause of cardioprotection, since inhibition of autophagy abolished the protective efficacy. Furthermore, combination treatment with D942 and curcumin profoundly upregulated autophagy after OGD/R and significantly promoted cell survival. Treatment with D942 and curcumin significantly upregulated autophagy in a murine myocardial I/R model.
MedKoo Cat#: 563222
Name: AMPK activator D942
CAS#: 849727-81-7
Chemical Formula: C22H21FO4
Exact Mass: 368.1420
Molecular Weight: 368.40
Elemental Analysis: C, 71.73; H, 5.75; F, 5.16; O, 17.37
The following data is based on the product molecular weight 368.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
