Ketocillin sodium | CAS#196309-79-2 | semisynthetic penicillin

MedKoo Cat#: 558363 | Name: Ketocillin sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ketocillin sodium is a semisynthetic penicillin.

Chemical Structure

Ketocillin sodium

CAS#196309-79-2

Theoretical Analysis

MedKoo Cat#: 558363

Name: Ketocillin sodium

CAS#: 196309-79-2

Chemical Formula: C24H23N2NaO5S

Exact Mass: 474.1200

Molecular Weight: 474.51

Elemental Analysis: C, 60.75; H, 4.89; N, 5.90; Na, 4.84; O, 16.86; S, 6.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ketocillin sodium;

IUPAC/Chemical Name

sodium (2S,5R,6R)-6-(2-(3-benzoylphenyl)propanamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

InChi Key

GFBDCTHJMSNJTE-HBRXWCKGSA-L

InChi Code

InChI=1S/2C24H24N2O5S.2Na/c2*1-13(15-10-7-11-16(12-15)18(27)14-8-5-4-6-9-14)20(28)25-17-21(29)26-19(23(30)31)24(2,3)32-22(17)26;;/h2*4-13,17,19,22H,1-3H3,(H,25,28)(H,30,31);;/q;;2*+1/p-2/t2*13?,17-,19+,22-;;/m11../s1

SMILES Code

CC(c1cc(C(c2ccccc2)=O)ccc1)C(N[C@H]3[C@H]4SC(C)([C@H](C([O-])=O)N4C3=O)C)=O.O=C([C@@H](C(C)(C)S[C@]5([H])[C@@H]6NC(C(C7=CC=CC(C(C8=CC=CC=C8)=O)=C7)C)=O)N5C6=O)[O-].[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 474.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wei L, Mackenzie IS, MacDonald TM, George J. Cardiovascular risk associated with sodium-containing medicines. Expert Opin Drug Saf. 2014 Nov;13(11):1515-23. doi: 10.1517/14740338.2014.970163. Epub 2014 Oct 10. Review. PubMed PMID: 25300906. 2: Cogswell ME, Maalouf J, Elliott P, Loria CM, Patel S, Bowman BA. Use of Urine Biomarkers to Assess Sodium Intake: Challenges and Opportunities. Annu Rev Nutr. 2015;35:349-87. doi: 10.1146/annurev-nutr-071714-034322. Epub 2015 May 6. Review. PubMed PMID: 25974702; PubMed Central PMCID: PMC5497310. 3: Vegter S, Perna A, Postma MJ, Navis G, Remuzzi G, Ruggenenti P. Sodium intake, ACE inhibition, and progression to ESRD. J Am Soc Nephrol. 2012 Jan;23(1):165-73. doi: 10.1681/ASN.2011040430. Epub 2011 Dec 1. PubMed PMID: 22135311; PubMed Central PMCID: PMC3269916. 4: Basuray A, Dolansky M, Josephson R, Sattar A, Grady EM, Vehovec A, Gunstad J, Redle J, Fang J, Hughes JW. Dietary sodium adherence is poor in chronic heart failure patients. J Card Fail. 2015 Apr;21(4):323-9. doi: 10.1016/j.cardfail.2014.12.016. Epub 2015 Jan 7. PubMed PMID: 25576680; PubMed Central PMCID: PMC4395528. 5: Goldstein P, Leshem M. Dietary sodium, added salt, and serum sodium associations with growth and depression in the U.S. general population. Appetite. 2014 Aug;79:83-90. doi: 10.1016/j.appet.2014.04.008. Epub 2014 Apr 18. PubMed PMID: 24747212. 6: Amer M, Woodward M, Appel LJ. Effects of dietary sodium and the DASH diet on the occurrence of headaches: results from randomised multicentre DASH-Sodium clinical trial. BMJ Open. 2014 Dec 11;4(12):e006671. doi: 10.1136/bmjopen-2014-006671. PubMed PMID: 25500372; PubMed Central PMCID: PMC4265150. 7: Kim MK, Lee KG. Consumer awareness and interest toward sodium reduction trends in Korea. J Food Sci. 2014 Jul;79(7):S1416-23. doi: 10.1111/1750-3841.12503. Epub 2014 Jun 28. PubMed PMID: 24975166. 8: Levings JL, Gunn JP. From menu to mouth: opportunities for sodium reduction in restaurants. Prev Chronic Dis. 2014 Jan 23;11:130237. doi: 10.5888/pcd11.130237. PubMed PMID: 24456646; PubMed Central PMCID: PMC3900328. 9: Lopez-Jaramillo P, Lopez-Lopez J, Lopez-Lopez C. Sodium Intake Recommendations: A Subject that Needs to be Reconsidered. Curr Hypertens Rev. 2015;11(1):8-13. PubMed PMID: 26028242. 10: Korošec Ž, Pravst I. Assessing the average sodium content of prepacked foods with nutrition declarations: the importance of sales data. Nutrients. 2014 Sep 4;6(9):3501-15. doi: 10.3390/nu6093501. PubMed PMID: 25192028; PubMed Central PMCID: PMC4179173. 11: McLean R, Hoek J. Sodium and nutrition labelling: a qualitative study exploring New Zealand consumers' food purchasing behaviours. Public Health Nutr. 2014 May;17(5):1138-46. doi: 10.1017/S1368980013001079. Epub 2013 May 7. PubMed PMID: 23651916. 12: McLean R, Edmonds J, Williams S, Mann J, Skeaff S. Balancing Sodium and Potassium: Estimates of Intake in a New Zealand Adult Population Sample. Nutrients. 2015 Oct 28;7(11):8930-8. doi: 10.3390/nu7115439. Erratum in: Nutrients. 2016 Feb;8(2):65. PubMed PMID: 26516912; PubMed Central PMCID: PMC4663567. 13: Mendoza JE, Schram GA, Arcand J, Henson S, L'Abbe M. Assessment of consumers’ level of engagement in following recommendations for lowering sodium intake. Appetite. 2014 Feb;73:51-7. PubMed PMID: 24511619. 14: Lu H, Wu C, Howatt DA, Balakrishnan A, Charnigo RJ Jr, Cassis LA, Daugherty A. Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice. J Nutr Biochem. 2013 Jan;24(1):49-53. doi: 10.1016/j.jnutbio.2012.03.001. Epub 2012 Jun 15. PubMed PMID: 22705323; PubMed Central PMCID: PMC3568659. 15: Rhee MY, Shin SJ, Park SH, Kim SW. Sodium intake of a city population in Korea estimated by 24-h urine collection method. Eur J Clin Nutr. 2013 Aug;67(8):875-80. doi: 10.1038/ejcn.2013.87. Epub 2013 May 1. PubMed PMID: 23632748. 16: Graudal N, Hubeck-Graudal T, Jürgens G, McCarron DA. The significance of duration and amount of sodium reduction intervention in normotensive and hypertensive individuals: a meta-analysis. Adv Nutr. 2015 Mar 13;6(2):169-77. doi: 10.3945/an.114.007708. Print 2015 Mar. Review. Erratum in: Adv Nutr. 2015 May;6(3):285. PubMed PMID: 25770255; PubMed Central PMCID: PMC4352175. 17: McLaren L, Heidinger S, Dutton DJ, Tarasuk V, Campbell NR. A repeated cross-sectional study of socio-economic inequities in dietary sodium consumption among Canadian adults: implications for national sodium reduction strategies. Int J Equity Health. 2014 Jun 5;13:44. doi: 10.1186/1475-9276-13-44. PubMed PMID: 24903535; PubMed Central PMCID: PMC4058444. 18: Antman EM, Appel LJ, Balentine D, Johnson RK, Steffen LM, Miller EA, Pappas A, Stitzel KF, Vafiadis DK, Whitsel L. Stakeholder discussion to reduce population-wide sodium intake and decrease sodium in the food supply: a conference report from the American Heart Association Sodium Conference 2013 Planning Group. Circulation. 2014 Jun 24;129(25):e660-79. doi: 10.1161/CIR.0000000000000051. Epub 2014 May 5. PubMed PMID: 24799511. 19: Bi Z, Liang X, Xu A, Wang L, Shi X, Zhao W, Ma J, Guo X, Zhang X, Zhang J, Ren J, Yan L, Lu Z, Wang H, Tang J, Cai X, Dong J, Zhang J, Chu J, Engelgau M, Yang Q, Hong Y, Wang Y. Hypertension prevalence, awareness, treatment, and control and sodium intake in Shandong Province, China: baseline results from Shandong-Ministry of Health Action on Salt Reduction and Hypertension (SMASH), 2011. Prev Chronic Dis. 2014 May 22;11:E88. doi: 10.5888/pcd11.130423. PubMed PMID: 24854239; PubMed Central PMCID: PMC4032056. 20: Spencer AG, Greasley PJ. Pharmacologic inhibition of intestinal sodium uptake: a gut centric approach to sodium management. Curr Opin Nephrol Hypertens. 2015 Sep;24(5):410-6. doi: 10.1097/MNH.0000000000000154. Review. PubMed PMID: 26197202.