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MedKoo Cat#: 597518 | Name: Collagen type IV alpha1 (531-543)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Collagen type IV alpha1 (531-543) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. Mutations in the gene have been linked to diseases of the brain, muscle, kidney, eye, and cardiovascular system. The COL4A1 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease. It is active in directly promoting keratinocyte adhesion.

Chemical Structure

Collagen type IV alpha1 (531-543)
CAS#119953-02-5

Theoretical Analysis

MedKoo Cat#: 597518

Name: Collagen type IV alpha1 (531-543)

CAS#: 119953-02-5

Chemical Formula: C74H110N18O21

Exact Mass: 1586.8093

Molecular Weight: 1587.79

Elemental Analysis: C, 55.98; H, 6.98; N, 15.88; O, 21.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Collagen type IV alpha1 (531-543); Hep III peptide; Gefyfdlrlkgdk;
IUPAC/Chemical Name
L-Lysine, glycyl-L-alpha-glutamyl-L-phenylalanyl-L-tyrosyl-L-phenylalanyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-leucyl-L-lysylglycyl-L-alpha-aspartyl-
InChi Key
LZLBNEPMZQVGQQ-FCDAVOGYSA-N
InChi Code
InChI=1S/C74H110N18O21/c1-41(2)32-51(66(105)84-47(20-11-13-29-75)63(102)81-40-59(95)83-56(37-61(98)99)71(110)86-50(73(112)113)21-12-14-30-76)87-64(103)48(22-15-31-80-74(78)79)85-67(106)52(33-42(3)4)88-72(111)57(38-62(100)101)92-70(109)54(35-44-18-9-6-10-19-44)90-69(108)55(36-45-23-25-46(93)26-24-45)91-68(107)53(34-43-16-7-5-8-17-43)89-65(104)49(27-28-60(96)97)82-58(94)39-77/h5-10,16-19,23-26,41-42,47-57,93H,11-15,20-22,27-40,75-77H2,1-4H3,(H,81,102)(H,82,94)(H,83,95)(H,84,105)(H,85,106)(H,86,110)(H,87,103)(H,88,111)(H,89,104)(H,90,108)(H,91,107)(H,92,109)(H,96,97)(H,98,99)(H,100,101)(H,112,113)(H4,78,79,80)/t47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1
SMILES Code
NCCCC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC3=CC=CC=C3)NC([C@H](CCC(O)=O)NC(CN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,587.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wilke MS, Furcht LT. Human keratinocytes adhere to a unique heparin-binding peptide sequence within the triple helical region of type IV collagen. J Invest Dermatol. 1990 Sep;95(3):264-70. PubMed PMID: 2384687. 2: Kim JP, Chen JD, Wilke MS, Schall TJ, Woodley DT. Human keratinocyte migration on type IV collagen. Roles of heparin-binding site and alpha 2 beta 1 integrin. Lab Invest. 1994 Sep;71(3):401-8. PubMed PMID: 7933990. 3: Miles AJ, Skubitz AP, Furcht LT, Fields GB. Promotion of cell adhesion by single-stranded and triple-helical peptide models of basement membrane collagen alpha 1(IV)531-543. Evidence for conformationally dependent and conformationally independent type IV collagen cell adhesion sites. J Biol Chem. 1994 Dec 9;269(49):30939-45. PubMed PMID: 7983028. 4: Toth M, Sado Y, Ninomiya Y, Fridman R. Biosynthesis of alpha2(IV) and alpha1(IV) chains of collagen IV and interactions with matrix metalloproteinase-9. J Cell Physiol. 1999 Jul;180(1):131-9. PubMed PMID: 10362026. 5: Siddiqua LK. Glomerular expression of collagen IV alpha 1, alpha 3 and alpha 5 chains in childhood IgA nephropathy. Hokkaido Igaku Zasshi. 2001 Mar;76(2):85-92. PubMed PMID: 11344905. 6: Pföhler C, Fixemer T, Jung V, Dooley S, Remberger K, Bonkhoff H. In situ hybridization analysis of genes coding collagen IV alpha1 chain, laminin beta1 chain, and S-laminin in prostate tissue and prostate cancer: increased basement membrane gene expression in high-grade and metastatic lesions. Prostate. 1998 Aug 1;36(3):143-50. PubMed PMID: 9687985.