Leucyl-leucyl-leucine | CAS#10329-75-6 | endosome escape moiety

MedKoo Cat#: 597456 | Name: Leucyl-leucyl-leucine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucyl-leucyl-leucine is an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Chemical Structure

Leucyl-leucyl-leucine

CAS#10329-75-6

Theoretical Analysis

MedKoo Cat#: 597456

Name: Leucyl-leucyl-leucine

CAS#: 10329-75-6

Chemical Formula: C18H35N3O4

Exact Mass: 357.2628

Molecular Weight: 357.49

Elemental Analysis: C, 60.48; H, 9.87; N, 11.75; O, 17.90

Price and Availability

Size	Price	Availability	Quantity
500mg	USD 340.00
1g	USD 550.00

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Related CAS #

No Data

Synonym

Leucyl-leucyl-leucine; Trileucine;

IUPAC/Chemical Name

L-leucyl-L-leucyl-L-leucine

InChi Key

DNDWZFHLZVYOGF-KKUMJFAQSA-N

InChi Code

InChI=1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)/t13-,14-,15-/m0/s1

SMILES Code

CC(C)C[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)N)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 357.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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