IDI-3783 | CAS#901031-43-4 | PfDHODH inhibitor

MedKoo Cat#: 563175 | Name: IDI-3783

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDI-3783 is a mutant-selective Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor.

Chemical Structure

IDI-3783

CAS#901031-43-4

Theoretical Analysis

MedKoo Cat#: 563175

Name: IDI-3783

CAS#: 901031-43-4

Chemical Formula: C26H23ClFN3O2S

Exact Mass: 495.1184

Molecular Weight: 495.99

Elemental Analysis: C, 62.96; H, 4.67; Cl, 7.15; F, 3.83; N, 8.47; O, 6.45; S, 6.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IDI-3783; IDI 3783; IDI3783;

IUPAC/Chemical Name

10-[(2-Chloro-6-fluorophenyl)methyl]-8-[(4-methyl-1-piperazinyl)carbonyl]-dibenzo[b,f][1,4]thiazepin-11(10H)-one

InChi Key

KHTBRACCSUODEU-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H23ClFN3O2S/c1-29-11-13-30(14-12-29)25(32)17-9-10-24-22(15-17)31(16-19-20(27)6-4-7-21(19)28)26(33)18-5-2-3-8-23(18)34-24/h2-10,15H,11-14,16H2,1H3

SMILES Code

O=C1N(CC2=C(F)C=CC=C2Cl)C3=CC(C(N4CCN(C)CC4)=O)=CC=C3SC5=CC=CC=C15

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 495.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):799-804. doi: 10.1073/pnas.1320886110. Epub 2013 Dec 31. PubMed PMID: 24381157; PubMed Central PMCID: PMC3896170.