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MedKoo Cat#: 597444 | Name: ISS-221

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ISS-221 is a bioactive chemical.

Chemical Structure

ISS-221
ISS-221
CAS#725233-59-0

Theoretical Analysis

MedKoo Cat#: 597444

Name: ISS-221

CAS#: 725233-59-0

Chemical Formula: C22H28N3O8P

Exact Mass: 493.1614

Molecular Weight: 493.45

Elemental Analysis: C, 53.55; H, 5.72; N, 8.52; O, 25.94; P, 6.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ISS-221; ISS 221; ISS221;
IUPAC/Chemical Name
((S)-2-(2-methylnicotinamido)-3-(4-(phosphonooxy)phenyl)propanoyl)-L-leucine
InChi Key
ICNHZQNUQZCDSZ-OALUTQOASA-N
InChi Code
InChI=1S/C22H28N3O8P/c1-13(2)11-19(22(28)29)25-21(27)18(24-20(26)17-5-4-10-23-14(17)3)12-15-6-8-16(9-7-15)33-34(30,31)32/h4-10,13,18-19H,11-12H2,1-3H3,(H,24,26)(H,25,27)(H,28,29)(H2,30,31,32)/t18-,19-/m0/s1
SMILES Code
CC(C)C[C@@H](C(O)=O)NC([C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C2=CC=CN=C2C)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Felicetti F, De Feo A, Coscia C, Puglisi R, Pedini F, Pasquini L, Bellenghi M, Errico MC, Pagani E, Carè A. Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma. J Transl Med. 2016 Feb 24;14:56. doi: 10.1186/s12967-016-0811-2. PubMed PMID: 26912358; PubMed Central PMCID: PMC4765208. 2: Blom MC, Aspelin L, Ivarsson K. Propensity for performing interventions in pre-hospital trauma management - a comparison between physicians and non-physicians. J Trauma Manag Outcomes. 2014 Feb 7;8(1):3. doi: 10.1186/1752-2897-8-3. PubMed PMID: 24502224; PubMed Central PMCID: PMC3942262. 3: Gabbianelli M, Testa U, Morsilli O, Pelosi E, Saulle E, Petrucci E, Castelli G, Giovinazzi S, Mariani G, Fiori ME, Bonanno G, Massa A, Croce CM, Fontana L, Peschle C. Mechanism of human Hb switching: a possible role of the kit receptor/miR 221-222 complex. Haematologica. 2010 Aug;95(8):1253-60. doi: 10.3324/haematol.2009.018259. Epub 2010 Mar 19. PubMed PMID: 20305142; PubMed Central PMCID: PMC2913072. 4: Mörs K, Braun O, Wagner N, Auner B, Voth M, Störmann P, Wutzler S, Marzi I, Relja B. Influence of gender on systemic IL-6 levels, complication rates and outcome after major trauma. Immunobiology. 2016 Aug;221(8):904-10. doi: 10.1016/j.imbio.2016.03.005. Epub 2016 Mar 18. PubMed PMID: 27017325. 5: Schmidt U, Frame SB, Nerlich ML, Rowe DW, Enderson BL, Maull KI, Tscherne H. On-scene helicopter transport of patients with multiple injuries--comparison of a German and an American system. J Trauma. 1992 Oct;33(4):548-53; discussion 553-5. PubMed PMID: 1433401. 6: Felicetti F, Errico MC, Segnalini P, Mattia G, Carè A. MicroRNA-221 and -222 pathway controls melanoma progression. Expert Rev Anticancer Ther. 2008 Nov;8(11):1759-65. doi: 10.1586/14737140.8.11.1759. Review. PubMed PMID: 18983236. 7: Ziapour A, Kianipour N. Association among character attributes and mental health among the staff in Medical Sciences Kermanshah University in 2015. J Med Life. 2015;8(Spec Iss 3):122-128. PubMed PMID: 28316678; PubMed Central PMCID: PMC5348945. 8: Hannon E, Potter S, Jaiganesh T, Muhktar Z, Okoye B. The impact of adult major trauma centre status on paediatric trauma activity. Emerg Med J. 2013 Oct;30(10):828-30. doi: 10.1136/emermed-2012-201125. Epub 2012 Oct 17. PubMed PMID: 23076985. 9: Lustenberger T, Kern M, Relja B, Wutzler S, Störmann P, Marzi I. The effect of brain injury on the inflammatory response following severe trauma. Immunobiology. 2016 Mar;221(3):427-31. doi: 10.1016/j.imbio.2015.11.011. Epub 2015 Nov 27. PubMed PMID: 26688509. 10: Dueck A, Poenaru D, Pichora DR. Cost factors in Canadian pediatric trauma. Can J Surg. 2001 Apr;44(2):117-21. PubMed PMID: 11308233; PubMed Central PMCID: PMC3695105. 11: Schmidt U, Muggia-Sullam M, Holch M, Kant CJ, Brummerloh C, Frame SB, Rowe DW, Enderson BL, Nerlich M, Maull KI, et al. [Primary management of polytrauma. Comparison of a German and American air rescue unit]. Unfallchirurg. 1993 Jun;96(6):287-91. German. PubMed PMID: 8342055. 12: Tan D, Ong KH, Koh LP, Wong SS, Khin MT, Lee LH, Goh YT, Chng WJ. The impact of frontline risk-adapted strategy on the overall survival of patients with newly diagnosed multiple myeloma: an analysis of the Singapore multiple myeloma study group. Eur J Haematol. 2012 Aug;89(2):136-44. doi: 10.1111/j.1600-0609.2012.01797.x. Epub 2012 Jun 21. PubMed PMID: 22553948. 13: Machado-Aranda DA, Jakubus JL, Wahl WL, Cherry-Bukowiec JR, To KB, Park PK, Raghavendran K, Napolitano LM, Hemmila MR. Reduction in Venous Thromboembolism Events: Trauma Performance Improvement and Loop Closure Through Participation in a State-Wide Quality Collaborative. J Am Coll Surg. 2015 Sep;221(3):661-8. doi: 10.1016/j.jamcollsurg.2015.05.006. Epub 2015 Jun 10. PubMed PMID: 26195250. 14: Pommerening MJ, Goodman MD, Holcomb JB, Wade CE, Fox EE, Del Junco DJ, Brasel KJ, Bulger EM, Cohen MJ, Alarcon LH, Schreiber MA, Myers JG, Phelan HA, Muskat P, Rahbar M, Cotton BA; MPH on behalf of the PROMMTT Study Group. Clinical gestalt and the prediction of massive transfusion after trauma. Injury. 2015 May;46(5):807-13. doi: 10.1016/j.injury.2014.12.026. Epub 2015 Feb 4. PubMed PMID: 25682314; PubMed Central PMCID: PMC4800814. 15: Riccioni R, Lulli V, Castelli G, Biffoni M, Tiberio R, Pelosi E, Lo-Coco F, Testa U. miR-21 is overexpressed in NPM1-mutant acute myeloid leukemias. Leuk Res. 2015 Feb;39(2):221-8. doi: 10.1016/j.leukres.2014.11.001. Epub 2014 Nov 18. PubMed PMID: 25543261. 16: Fonseca AH, Ochsner MG, Bromberg WJ, Gantt D. All-terrain vehicle injuries: are they dangerous? A 6-year experience at a level I trauma center after legislative regulations expired. Am Surg. 2005 Nov;71(11):937-40; discussion 940-1. PubMed PMID: 16372612. 17: Kobbe P, Micansky F, Lichte P, Sellei RM, Pfeifer R, Dombroski D, Lefering R, Pape HC; TraumaRegister DGU. Increased morbidity and mortality after bilateral femoral shaft fractures: myth or reality in the era of damage control? Injury. 2013 Feb;44(2):221-5. doi: 10.1016/j.injury.2012.09.011. Epub 2012 Oct 4. PubMed PMID: 23040674. 18: Carradori S, Pierini M, Menta S, Secci D, Fioravanti R, Cirilli R. 3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: A fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethylphenylcarbamate) chiral stationary phase. Part I. Structure-enantioselectivity relationships. J Chromatogr A. 2016 Oct 7;1467:221-227. doi: 10.1016/j.chroma.2016.07.034. Epub 2016 Jul 15. PubMed PMID: 27461921. 19: Cestero RF, Plurad D, Green D, Inaba K, Putty B, Benfield R, Lam L, Talving P, Demetriades D. Iliac artery injuries and pelvic fractures: a national trauma database analysis of associated injuries and outcomes. J Trauma. 2009 Oct;67(4):715-8. doi: 10.1097/TA.0b013e3181af6e88. PubMed PMID: 19820576. 20: Svenson J. Trauma systems and timing of patient transfer: are we improving? Am J Emerg Med. 2008 May;26(4):465-8. doi: 10.1016/j.ajem.2007.05.013. PubMed PMID: 18410817.