RMM-46 | CAS#1307896-46-3 | MSK/RSK inhibitor

MedKoo Cat#: 563166 | Name: RMM-46

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

RMM-46 is a selective and reversible covalent inhibitor for MSK/RSK-family kinases.

Chemical Structure

RMM-46

CAS#1307896-46-3

Theoretical Analysis

MedKoo Cat#: 563166

Name: RMM-46

CAS#: 1307896-46-3

Chemical Formula: C24H26N4O5

Exact Mass: 450.1903

Molecular Weight: 450.49

Elemental Analysis: C, 63.99; H, 5.82; N, 12.44; O, 17.76

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 350.00	2 Weeks
5mg	USD 700.00	2 Weeks

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Synonym

RMM-46; RMM 46; RMM46;

IUPAC/Chemical Name

2-Cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide

InChi Key

FCCMYBKAZCDQGX-LZYBPNLTSA-N

InChi Code

InChI=1S/C24H26N4O5/c1-24(2,13-29)26-23(30)16(12-25)8-14-6-7-18-17(9-14)21(28-27-18)15-10-19(31-3)22(33-5)20(11-15)32-4/h6-11,29H,13H2,1-5H3,(H,26,30)(H,27,28)/b16-8+

SMILES Code

O=C(NC(C)(C)CO)/C(C#N)=C/C1=CC2=C(NN=C2C3=CC(OC)=C(OC)C(OC)=C3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>3 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

RMM-46 is an inhibitor for MSK/RSK-family kinases.

In vitro activity:

This study showed that RMM-46 is a reversible covalent inhibitor that exhibits high ligand efficiency and selectivity for MSK/RSK-family kinases. At nanomolar concentrations, RMM-46 blocked activation of cellular MSK and RSK, as well as downstream phosphorylation of CREB. Reference: J Am Chem Soc. 2013 Apr 10;135(14):5298-301. https://pubmed.ncbi.nlm.nih.gov/23540679/

In vivo activity:

To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 450.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J Am Chem Soc. 2013 Apr 10;135(14):5298-301. doi: 10.1021/ja401221b. Epub 2013 Mar 29. PMID: 23540679; PMCID: PMC3665406.

In vitro protocol:

In vivo protocol:

To be determined

1: Miller RM, Paavilainen VO, Krishnan S, Serafimova IM, Taunton J. Electrophilic fragment-based design of reversible covalent kinase inhibitors. J Am Chem Soc. 2013 Apr 10;135(14):5298-301. doi: 10.1021/ja401221b. Epub 2013 Mar 29. PubMed PMID: 23540679; PubMed Central PMCID: PMC3665406.