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MedKoo Cat#: 558344 | Name: Chlordecone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlordecone is an organochlorine insecticide.

Chemical Structure

Chlordecone
Chlordecone
CAS#143-50-0

Theoretical Analysis

MedKoo Cat#: 558344

Name: Chlordecone

CAS#: 143-50-0

Chemical Formula: C10Cl10O

Exact Mass: 485.6800

Molecular Weight: 490.61

Elemental Analysis: C, 24.48; Cl, 72.26; O, 3.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Chlordecone; Kepone;
IUPAC/Chemical Name
1,3,4-Metheno-2H-cyclobuta(cd)pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-
InChi Key
LHHGDZSESBACKH-UHFFFAOYSA-N
InChi Code
InChI=1S/C10Cl10O/c11-2-1(21)3(12)6(15)4(2,13)8(17)5(2,14)7(3,16)9(6,18)10(8,19)20
SMILES Code
O=C1C2(Cl)C3(Cl)C4(Cl)C(Cl)(Cl)C5(Cl)C3(Cl)C1(Cl)C5(Cl)C24Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 490.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Costet N, Pelé F, Comets E, Rouget F, Monfort C, Bodeau-Livinec F, Linganiza EM, Bataille H, Kadhel P, Multigner L, Cordier S. Perinatal exposure to chlordecone and infant growth. Environ Res. 2015 Oct;142:123-34. doi: 10.1016/j.envres.2015.06.023. Epub 2015 Jun 30. PubMed PMID: 26133809. 2: Merlin C, Devers M, Crouzet O, Heraud C, Steinberg C, Mougin C, Martin-Laurent F. Characterization of chlordecone-tolerant fungal populations isolated from long-term polluted tropical volcanic soil in the French West Indies. Environ Sci Pollut Res Int. 2014 Apr;21(7):4914-27. doi: 10.1007/s11356-013-1971-8. Epub 2013 Jul 20. PubMed PMID: 23872892. 3: Cordier S, Bouquet E, Warembourg C, Massart C, Rouget F, Kadhel P, Bataille H, Monfort C, Boucher O, Muckle G, Multigner L. Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies). Environ Res. 2015 Apr;138:271-8. doi: 10.1016/j.envres.2015.02.021. Epub 2015 Mar 3. PubMed PMID: 25747818. 4: Florence C, Philippe L, Magalie LJ. Organochlorine (chlordecone) uptake by root vegetables. Chemosphere. 2015 Jan;118:96-102. doi: 10.1016/j.chemosphere.2014.06.076. Epub 2014 Jul 17. PubMed PMID: 25043888. 5: Kadhel P, Monfort C, Costet N, Rouget F, Thomé JP, Multigner L, Cordier S. Chlordecone exposure, length of gestation, and risk of preterm birth. Am J Epidemiol. 2014 Mar 1;179(5):536-44. doi: 10.1093/aje/kwt313. Epub 2014 Jan 8. PubMed PMID: 24401561. 6: Martin-Laurent F, Sahnoun MM, Merlin C, Vollmer G, Lübke M. Detection and quantification of chlordecone in contaminated soils from the French West Indies by GC-MS using the 13C10-chlordecone stable isotope as a tracer. Environ Sci Pollut Res Int. 2014 Apr;21(7):4928-33. doi: 10.1007/s11356-013-1839-y. Epub 2013 Jun 4. PubMed PMID: 23733305. 7: Gaume B, Dodet N, Thomé JP, Lemoine S. Expression of biotransformation and oxidative stress genes in the giant freshwater prawn Macrobrachium rosenbergii exposed to chlordecone. Environ Sci Pollut Res Int. 2015 Jun;22(11):7991-8002. doi: 10.1007/s11356-014-3134-y. Epub 2014 Jun 13. PubMed PMID: 24920261. 8: Saunders L, Kadhel P, Costet N, Rouget F, Monfort C, Thomé JP, Guldner L, Cordier S, Multigner L. Hypertensive disorders of pregnancy and gestational diabetes mellitus among French Caribbean women chronically exposed to chlordecone. Environ Int. 2014 Jul;68:171-6. doi: 10.1016/j.envint.2014.03.024. Epub 2014 Apr 15. PubMed PMID: 24727072. 9: Lagarrigue M, Lavigne R, Tabet E, Genet V, Thomé JP, Rondel K, Guével B, Multigner L, Samson M, Pineau C. Localization and in situ absolute quantification of chlordecone in the mouse liver by MALDI imaging. Anal Chem. 2014 Jun 17;86(12):5775-83. doi: 10.1021/ac500313s. Epub 2014 Jun 3. PubMed PMID: 24837422. 10: Bichon E, Guiffard I, Vénisseau A, Marchand P, Antignac JP, Le Bizec B. Ultra-trace quantification method for chlordecone in human fluids and tissues. J Chromatogr A. 2015 Aug 21;1408:169-77. doi: 10.1016/j.chroma.2015.07.013. Epub 2015 Jul 8. PubMed PMID: 26184709. 11: Clostre F, Cattan P, Gaude JM, Carles C, Letourmy P, Lesueur-Jannoyer M. Comparative fate of an organochlorine, chlordecone, and a related compound, chlordecone-5b-hydro, in soils and plants. Sci Total Environ. 2015 Nov 1;532:292-300. doi: 10.1016/j.scitotenv.2015.06.026. Epub 2015 Jun 14. PubMed PMID: 26081731. 12: Jurjanz S, Jondreville C, Mahieu M, Fournier A, Archimède H, Rychen G, Feidt C. Relative bioavailability of soil-bound chlordecone in growing lambs. Environ Geochem Health. 2014 Oct;36(5):911-7. doi: 10.1007/s10653-014-9608-5. Epub 2014 Apr 13. PubMed PMID: 24729076. 13: Fernández-Bayo JD, Saison C, Voltz M, Disko U, Hofmann D, Berns AE. Chlordecone fate and mineralisation in a tropical soil (andosol) microcosm under aerobic conditions. Sci Total Environ. 2013 Oct 1;463-464:395-403. doi: 10.1016/j.scitotenv.2013.06.044. Epub 2013 Jul 2. PubMed PMID: 23827360. 14: Jondreville C, Fournier A, Mahieu M, Feidt C, Archimède H, Rychen G. Kinetic study of chlordecone orally given to laying hens (Gallus domesticus). Chemosphere. 2014 Nov;114:275-81. doi: 10.1016/j.chemosphere.2014.05.008. Epub 2014 Jun 2. PubMed PMID: 25113213. 15: Tabet E, Genet V, Tiaho F, Lucas-Clerc C, Gelu-Simeon M, Piquet-Pellorce C, Samson M. Chlordecone potentiates hepatic fibrosis in chronic liver injury induced by carbon tetrachloride in mice. Toxicol Lett. 2016 Jul 25;255:1-10. doi: 10.1016/j.toxlet.2016.02.005. Epub 2016 Feb 4. PubMed PMID: 26853152. 16: Boucher O, Simard MN, Muckle G, Rouget F, Kadhel P, Bataille H, Chajès V, Dallaire R, Monfort C, Thomé JP, Multigner L, Cordier S. Exposure to an organochlorine pesticide (chlordecone) and development of 18-month-old infants. Neurotoxicology. 2013 Mar;35:162-8. doi: 10.1016/j.neuro.2013.01.007. Epub 2013 Jan 29. PubMed PMID: 23376090. 17: Clostre F, Letourmy P, Thuriès L, Lesueur-Jannoyer M. Effect of home food processing on chlordecone (organochlorine) content in vegetables. Sci Total Environ. 2014 Aug 15;490:1044-50. doi: 10.1016/j.scitotenv.2014.05.082. Epub 2014 Jun 7. PubMed PMID: 24914532. 18: Létondor C, Pascal-Lorber S, Laurent F. Uptake and distribution of chlordecone in radish: different contamination routes in edible roots. Chemosphere. 2015 Jan;118:20-8. doi: 10.1016/j.chemosphere.2014.03.102. Epub 2014 Jun 19. PubMed PMID: 25433399. 19: Lafontaine A, Hanikenne M, Boulangé-Lecomte C, Forget-Leray J, Thomé JP, Gismondi E. Vitellogenin and vitellogenin receptor gene expression and 20-hydroxyecdysone concentration in Macrobrachium rosenbergii exposed to chlordecone. Environ Sci Pollut Res Int. 2016 Oct;23(20):20661-20671. Epub 2016 Jul 28. PubMed PMID: 27470247. 20: Hervé D, Costet N, Kadhel P, Rouget F, Monfort C, Thomé JP, Multigner L, Cordier S. Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort. Environ Res. 2016 Nov;151:436-444. doi: 10.1016/j.envres.2016.08.004. Epub 2016 Aug 23. PubMed PMID: 27560981.